Bioactive Natural Products: Opportunities and Challenges in Medicinal Chemistry

Description

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Readership: Phytochemists; combinatorial chemists; pharmacologists; institutes for drug research (drug discovery and development); industrial research groups developing drugs from medicinal plants; pharmaceutical companies; manufacturers of herbal and ayurvedic medicines and cosmetic products; manufacturers of natural products; advanced and research students.

Table of Contents

• Natural Products in Drug Discovery: Impacts and Opportunities — An Assessment (Goutam Brahmachari)
• Vascular Regulation by Small Peptides (Toshiro Matsui, Zhengquan Wang and Mitsuru Tanaka)
• Key Natural Products in Malaria Chemotherapy: From Quinine to Artemisinin and Beyond (Jean Fotie)
• Natural Product Inhibitors and Activators of Histone Deacetylases (Michael D Scott, Manas K Haldar and Sanku Mallik)
• Artemisinin: A Promise for the Development of Potent Anticancer Agents (Daniel L da Silva, Luzia V Modolo, Ilza M O Sousa, Rodney A F Rodrigues, Mary Ann Foglio and Ângelo de Fátima)
• Andrographolide: A Plant-Derived Natural Molecule of Pharmaceutical Promise (Goutam Brahmachari)
• Natural Products in Alzheimer's Disease: Impacts and Prospects (Shri Kant Mishra, Mark C Stahl and Parampreet Singh)
• Use of Multi-nutrient Functional Peptide Complex ≪GRINIZATION≫ for Treatment and Prevention of Viral Infections (Viktor Lozitsky, Alla Fedchuk, Irina Gomolyako, Ivan Chekman, Anatoliy Bulavka, Galyna Anokhina, Georgiy Donchenko, Sergiy Pozdnyakov, Xeniya Igrunova, Tetyana Grydina, Lidiya Socheslo, Liubov Mudryk, Nataliya Klochkova, Larysa Shytikova, Valentina Pushkina, Olga Golubovska, Vladimir Shestakov and Anatoliy Pechinka)
• Anti-Infective Flavonoids: An Overview (María José Abad, Luis Miguel Bedoya, Luis Apaza and Paulina Bermejo)
• Anti-Helicobacter Pylori Activities of Compounds of Natural Origin (Temitope O Lawal, Kapil K Soni, R C Saxena, Bolanle A Adeniyi and Gail B Mahady)
• Natural Bioactive Principles in the Treatment of Skin Diseases (Emmanuel C Ibezim)
• Anti-Diabetic Agents of Natural Origin: A Retrospective Account of Some Promising Chemotypes (Goutam Brahmachari)
• Fermentation Improvement of Processes Yielding Natural Products for Industry (Arnold L Demain and Sergio Sanchez)
• Plant Cell Culture and Transgenic Plants: The Goldmines for the Production of Compounds of Pharmacological Interest (Ana Paula de Faria, Ângelo de Fátima, Vagner A Benedito and Luzia V Modolo)