Bone Marrow Transplantation across Major Genetic Barriers

Description

edited by Yair Reisner (Weizmann Institute of Science, Israel) & Massimo F Martelli (Perugia University, Italy)

The importance of bone marrow transplantation for patients who do not have a matched sibling donor cannot be overestimated. This subject has always been in the public domain, accentuated by dramatic appeals, from time to time, to search for matched volunteer donors in the public at large. Unfortunately, the availability of such donors is limited, due to the remarkable genetic diversity of humans. Thus, although registries of such volunteers now include more than eight million individuals, we still face the problem of finding a matched donor for about 30% of patients in need. To address this burning issue, extensive clinical and basic research is performed in leading institutes around the world.

This book presents updated accounts of the different aspects of this research. The scope of the book is very wide, including strategies to overcome graft vs. host (GVH) disease and graft rejection, cell therapy to prevent leukemia relapse, and a range of modalities to improve immune reconstitution after transplantation. In addition, new approaches to induce immune tolerance towards organ transplants by means of hematopoietic stem cell transplantation are extensively reviewed.

Contents:

• Crossing HLA Barriers by ‘Megadose’ Stem Cell Transplants (Y Reisner et al.)
• The Haploidentical Option for High-Risk Haematological Malignancies (F Aversa et al.)
• Haploidentical Allogeneic Hematopoietic Cell Transplantation in Adults Using CD3/CD19 Depletion and Reduced Intensity Conditioning (W A Bethge)
• Unmanipulated HLA-Mismatched/Haploidentical Blood and Marrow Hematopoietic Stem Cell Transplantation (X-J Huang)
• Alloanergization in Haploidentical Hematopoietic Stem Cell Transplantation (J K Davies et al.)
• Hematopoietic Stem Cell Transplantation Across Genetic Barriers Using a Nonmyeloablative Conditioning Regimen (L-P Koh et al.)
• Deploying Natural Killer Cell Allotherapy in the Setting of HLA-Haplotype-Mismatched Hematopoietic Stem Cell Transplantation (A Velardi et al.)
• Adoptive Immunotherapy for Prophylaxis and Therapy of Infectious Complications After Allogeneic Hematopoietic Stem Cell Transplantation (M Kapp et al.)
• The Challenge in Hematopoietic Stem Cell Transplantation: Shortening the Immunodeficiency Period (L D Cortivo et al.)
• Treatment of Adenovirus Infection After Haploidentical Stem Cell Transplantation in Children (T Feuchtinger et al.)
• Regulatory T Cell Therapy for Immunomodulation After Allogeneic Hematopoietic Cell Transplantation (R Zeiser & R S Negrin)
• Pathogen-Induced Immune Regulation in Transplantation (L Romani)
• Immune Reconstitution After Haploidentical Hematopoietic Stem Cell Transplantation (A Shah et al.)
• The Role of the Thymus in Hematopoietic Stem Cell Transplantation (W Krenger & G A Holländer)
• Human T Cell Differentiation: New Techniques, Old Challenges (J Plum et al.)
• Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation (S Ghorashian et al.)
• Alloreactive T Cells for the Treatment of Leukemia (J H Frederik Falkenburg)
• Mobilization of Hematopoietic Stem and Progenitor Cells (K Lapid et al.)
• A Revolutionary BMT Method (S Ikehara)
• Hematopoietic Cell Transplantation for Induction of Transplantation Tolerance: From Animal Models to Clinical Trials (M Sykes)

Readership: Immunologists, oncologists, hematologists, geneticists and stem cell researchers.