Science of Wound Healing and Dressing Materials

1) Introduction 2) Pathophysiology of wound healing 3) Debridementa) Mechanical debridement: (i) Wet to dry (ii) Hydrotherapy (iii) Pulsed lavage (iv) Jetforce (v) Ultrasonic therapy b) Chemical/enzymatic : (i) Enzymes, (ii) Dakins solution, (iii) Eusole,c) Biological deridement: (i) Maggots therapyd) Autolytic debridement: e) Surgical/sharp debridement: 4) Antiseptics and local antibiotics 1. Merbromin 2. Acryflvineum Chloride 3.Chloroxylenol 4.Chlorhexidine 5.Hydrogen Peroxide 6.Benzoin resin 7.Neosporin/Bacitracin 8.Iodine (Cadoxemer, Povidone iodine) 9.Silver preparations (Elemental ions, inorganic compounds, organic complex) 10.Octenidine diyhdrochloride 11.Poly hexamethelene biguinide hydrochloride(PHMB) 12.Hypochlorous acid and sodium hypochlorite 13.Tetra chlorodecaoxide(TCDC) 14.Local Antibiotics 5) Absorbent dressings (simple gauze and others) 1.Foam dressings 2.Cotton and acrylic fiber dressings 3.Hydrocolloid dressings 4.Alginate dressings 5.Hydrofiber dressings 6. Ceramic dressings 6) Moisturizing dressings 1. Glycerine magnesium sulphate 2. Hydrogels 7) Other types of dressings: 1. Collagen dressings and combinations 2. Honey and sugar dressings 3. pH modulating dressings 4. Hyluronic acid 5. Hemoglobin spray 6. Dressing to control malodor 7. Local insulin treatment 8) Other modalities of treatment: 1. Oxygen therapy 2. Ozone therapy and low level laser therapy 3. Hyperbaric oxygen therapy (HBOT) 4. Negative pressure wound therapy (NPWT) 5. Electric therapy and Ultrasonic wound therapy 6. Extracorporial shock wave therapy (ESWT) 7. Compression therapy 9) Growth factors and hormones 10) Regenerative medicine: 1. Stem cells 2. Gene therapy 3. Cellular therapy 4. Skin and Living skin equivalents (LSEs) 11) Offloading, footwear and immobilization

This book outlines, from a surgeon's standpoint, how physicians and mid-level providers working at wound care centres can expeditiously and effectively manage wounds. It comprehensively addresses the concept of wound healing, from the healing process to debridement concepts, and various antiseptics and local antibiotics used in dressing materials to facilitate healing. The book also discusses the latest inventions and treatment options that have revolutionized wound healing, such as: oxygen therapy, ozone therapy, hyperbaric oxygen therapy, electric therapy and ultrasonic wound therapy. In closing, it examines the latest regenerative therapies based on stem cell therapy, cellular therapy and gene therapy.

Given its scope, the book offers a valuable resource for medical students and physicians dealing with wound management, as well as a reference guide for nurses in primary and tertiary wound care settings.

Dr Vibhakar vachhrajani, MBBS MS is a practicing surgeon with over 30 years of experience, and has worked in the area of diabetes and wound care for over two decades. Dr Vibhakar has trained at prestigious institutes such as Kings College London, Lutheran General Hospital, Chicago, and Raheja Hospital Mumbai. Apart from surgery he is also a keen researcher and has published his work in various journals across the globe. Dr Vibhakar has also given lectures at various platforms at the national and international levels. He has organized more than 100 public awareness programmes to prevent limb amputation, and is currently running a tertiary care centre for diabetic foot and wound management in Rajkot.

Dr Payal khakhkhar, B.H.M.S has over 7 years of experience in diabetes and wound care management at various prominent institutions such as: Government Hospital Rajkot, Gujrat, Pediatric Hospital, Rajkot and Vijay Vachhrajani Memorial Hospital, Rajkot. As an avid researcher, she has participated in Phase 3 clinical trials on wound management protocols at national and international institutions. She is also a trained diabetes educator from V Mohan's institute of Diabetology, Chennai and has held various lectures in the field of diabetes prevention at the national level.