Myopia. Animal Models to Clinical Trials

Description

Myopia is the most common optical disorder in the world, and is on the rise in many countries, particularly in East Asia. The impact of myopia is evident as the driving force in the development of refractive surgery and of the spectacle and contact lens industries. While myopia is often seen as a childhood disease that involves complex genetic-environmental factors, it is also a major cause of adult blindness. In Singapore (where myopia has reached one of the highest rates in the world) as well as in Taiwan, Japan and Hong Kong, affected patients have greater severity of myopia, leading to additional secondary complications such as glaucoma.

This book provides a comprehensive coverage of all aspects of myopia. It is aimed at ophthalmologists, optometrists, opticians, scientists and pharmaceutical companies. The topics are uniquely treated in that they cover research at the laboratory bench as well as clinical applications and population-based approaches in epidemiology.

Edited by Roger W Beuerman (Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore & National University of Singapore, Singapore), Seang-Mei Saw (Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore & National University of Singapore, Singapore), Donald T H Tan (Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore & National University of Singapore, Singapore), & Tien-Yin Wong (Singapore Eye Research Institute, Singapore, Singapore National Eye Centre, Singapore & National University of Singapore, Singapore)

Contents:

• Epidemiology and Risk Factors:
  • Epidemiology of Myopia and Myopic Shift in Refraction (B E K Klein)
  • Environmental Risk Factors for Myopia in Children (W C J Low et al.)
  • Gene-Environment Interactions in the Aetiology of Myopia (I G Morgan & K A Rose)
  • The Economics of Myopia (M C C Lim & K D Frick)
• Clinical Studies and Pathologic Myopia:
  • Quality of Life and Myopia (E L Lamoureux & H-B Wong)
  • Ocular Morbidity of Pathological Myopia (V S E Jeganathan et al.)
  • Myopia and Glaucoma (S A Perera & T Aung)
  • The Myopic Retina (S-Y Lee)
  • Retinal Function (C D Luu & A W L Chia)
• Genetics of Myopia:
  • New Approaches in the Genetics of Myopia (L K Goh et al.)
  • Twin Studies and Myopia (M Schäche & P N Baird)
  • TIGR, TGFBI, cMET, HGF, Collagen Genes and Myopia (C-C Khor)
  • Statistical Analysis of Genome-wide Association Studies for Myopia (Y-J Li & Q Fan)
• Animal Models and the Biological Basis of Myopia:
  • The Relevance of Studies in Chicks for Understanding Myopia in Humans (J Wallman & D L Nickla)
  • The Mechanisms Regulating Scleral Change in Myopia (N A McBrien)
  • The Mouse Model of Myopia (F Schaeffel)
  • Gene Analysis in Experimental Animal Models of Myopia (R W Beuerman et al.)
• Interventions for Myopia:
  • Atropine and Other Pharmacological Approaches to Prevent Myopia (L M G Tong et al.)
  • Physical Factors in Myopia and Potential Therapies (W S Foulds & C D Luu)

Readership: Ophthalmologists, optometrists, opticians, vision scientists, pharmaceutical companies.