Structure-Function Relationships in Various Respiratory Systems. Connecting to the Next Generation

Part I Respiratory Control System 1 Anatomy and Physiology of Respiratory Control System: How Are Respiratory Controlling Cells Communicated in the Brain?2 Anatomy and Physiology of Chemical Regulatory Mechanisms in Respiration: How Does Chemical Regulation Work with Various Acid-base Disorders?3 Coordination of Swallowing and Breathing: How Is Respiratory Control System Connected to Swallowing System?

Part II Upper Airway 4 Anatomy and Function of Upper Airway During Sleep: What Are Essential Mechanisms Eliciting Apneas During Sleep?5 Instability of Upper Airway During Anesthesia and Sedation: How Is Upper Airway Instable During Anesthesia and Sedation?

Part III Lower Airway 6 Macroscopic and Microscopic Anatomy of Lower Airways, Acinus, and Alveolar Wall: What Is the Most Suitable Design for Gas Transport, Gas Mixing, and Gas Exchange in the Lung?7 Convective and Diffusive Mixing in Lower and Acinar Airways: Is diffusive Mixing Effective in the Lung Periphery? 8 Radiological Evaluation of Lower Airway Dimensions Deciding Ventilatory Dynamics: Can Radiologically-determined, Static Airway Structures Precisely Predict Ventilatory Dysfunction?9 Functional Properties of Lower Airway Estimated by Oscillometry: Is Oscillometry Useful for Detecting Lower-airway Abnormalities?

Part IV Acinus 10 Inhomogeneous Distribution of Ventilation-perfusion (VA/Q) and Diffusing Capacity-perfusion (D/Q) in the Lung: What Abnormal VA/Q and D/Q Distributions Are Detected in Diseased Lungs?11 Physiological Basis of Effective Alveolar-Arterial O2 Difference (AaDO2) and Effective Physiological Dead Space (VD/VT): Are AaDO2 and VD/VT Supported by Structurally and Physiologically Correct Knowledges?12 Oxygen Transport from Air to Tissues as an Integrated System: What Limits Maximal O2 Consumption in Health and Disease?

Part V Alveolar wall 13 Pathophysiological and Clinical Implication of Diffusing Capacity for CO (DLCO) and Krogh Factor (KCO): How Do DLCO and KCO Differentiate Various Lung Diseases?14 Basic Perspectives of Simultaneous Measurement of DLCO and DLNO: What Are the Most Legitimate Assumptions When Estimating DLCO and DLNO? 15 Reference Equations for Simultaneously Measured DLCO and DLNO: How Are Reference Equations Influenced by Age, Sex, and Anthropometric Variables? 16 Differential Diagnosis Based on Newly Developed Indicator of DLNO/DLCO: What Are Pathophysiological Backgrounds on DLNO/DLCO? 17 Clinical Significance of Simultaneous Measurements of DLCO and DLNO: Can DLCO and DLNO Differentiate Various Kinds of Lung Diseases?

This book elucidates the morphological backgrounds of various functional parameters of the human respiratory system, including the respiratory control system, dynamics of the upper and lower airways, gas transport and mixing in the lower airways, gas exchange in the acinus, and gas transfer through the alveolar wall. Presenting the latest findings on the interrelationships between morphology and physiology in the respiratory system, the book's goal is to provide a foundation for further exploring structure-function relationships in various respiratory systems, and to improve both the quality of basic science, and that of clinical medicine targeting the human respiratory system.

Edited and written by internationally recognized experts, Structure-Function Relationships in Various Respiratory Systems offers a valuable asset for all physicians and researchers engaging in clinical, physiological, or morphological work in the field of respiration. Moreover, it provides a practical guide for physicians, helping them make more precise pathophysiological decisions concerning patients with various types of lung disease, and will be of interest to respiratory physiologists and respiratory morphologists.

Volume Editor
Kazuhiro Yamaguchi, MD, PhD
Department of Respiratory Medicine, Tokyo Medical University, Tokyo, Japan
Division of Respiratory Medicine, Tohto Clinic, Kenko-Igaku Association, Tokyo, Japan

Series Editors
Hiroyuki Nakamura, Department of Respiratory Medicine, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan
Kazutetsu Aoshiba, Department of Respiratory Medicine, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan