Introduction to oral premalignant lesions including epidemiology.- Development, relevant anatomy and physiology of the oral cavity and mucosa.- Basic cellular and molecular biology to include the effects of carcinogens (smoking, alcohol, betel nut, HPV, chronic candida).- Pathophysiology of the transformation from normal mucosa to invasive malignancy (carcinogenesis) including dysplasia.- Leukoplakia including benign lesions.- Erythroplakia and erythroleukoplakia.-The lichenoid group of diseases including erosive and atrophic lichen planus.-Systemic diseases that are potentially pre-cancerous (iron deficiency anaemic, immunosuppression.- Clinical presentation of oral mucosal premalignant lesions (this will be a larger section), and include high and low risk lesions.- Diagnosis including biopsy techniques and other relevant investigations.- Management of premalignant disease of the oral mucosa with up to date clinical trials and adjuvant therapies. Role of surgery, laser treatments.- The future.
Oral squamous cell carcinoma (SCC) is the 13th commonest cancer worldwide, and the most common cancer in the Asian subcontinent due to the widespread habit of tobacco and betel nut chewing. Despite many advances in diagnosis and treatment, the survival statistics have only marginally improved. However our understanding of the disease process and transformation from pre-cancerous lesions of the oral mucosa to an invasive SCC cancer and their progression has expanded exponentially.
There are many conditions of the oral mucosa that can progress to an invasive malignancy. A thorough understanding of these conditions is a prerequisite for all those involved in the management of the diseases of the oral mucosa and head and neck region.
The recognition and timely treatment of potentially pre-malignant conditions of the oral cavity can minimize the change to an overt malignancy in many patients through patient education, appropriate treatment and surveillance.
In this book we cover relevant anatomy, biology, diagnosis and latest management strategies for pre-cancerous conditions that affect the oral mucosa. The respective chapters are written by expert contributors from around the world, lending the book a global perspective and making it an essential guide for all those involved in the management of pre-malignant lesions arising in this challenging anatomical region.
Peter Brennan MD, FRCS (Eng), FRCSI, Hon FRCS (Glasgow), FDS RCS (Eng) Professor Peter Brennan is a Consultant Oral and Maxillofacial Surgeon at the Queen Alexandra Hospital, Portsmouth, UK with an interest in head and neck oncology and reconstruction. He has a personal chair in surgery in recognition of his research and education profile, publishing over 530 papers to date as well as editing 5 major textbooks (including lead editor of the 2 volume Maxillofacial Surgery) used successfully worldwide. He is lead editor for the new Gray's Surgical Anatomy - sister to the famous Gray's Anatomy itself. Peter is committed to teaching and education at all levels and was previous Honorary Editor of the British Journal of Oral and Maxillofacial Surgery. In addition to reviewing for many reputed journals, he is the current editor of the Journal of Oral Pathology and Medicine- one of the most well respected journals in this specialty area. Peter has research interests in oral cancer, neck anatomy, patient safety and human factors.
Tom Aldridge, BDS MFDS BM FRCS. Tom Aldridge is an Oral and Maxillofacial Consultant in Queen Alexandra Hospital, Portsmouth, UK. He received his Bachelor of Dental Surgery from the University of Bristol in 2000 and Bachelor of Medicine from Southampton University in 2008. He completed basic surgical training and specialist training in Oral and Maxillofacial training in 2015. Tom specialises in facial trauma, orthognathic surgery, skin surgery and dentoalveolar surgery and has a keen in Medical Education and Training. He has published widely across the specialty and presented nationally and internationally.
Raghav Dwivedi, DOHNS, MS (ENT), FRCS (Glasg), PhD (Lond), FRCS (ORL-HNS). Raghav Dwivedi is a Consultant Head Neck Surgeon at the Queen Elizabeth University Hospital, Glasgow. He completed ENT and head neck surgery specialty training from the UK and India. He also completed head neck research fellowship at the Royal Marsden Hospital and the Institute of Cancer Research London and head neck surgical fellowships at Nottingham University Hospital, Cambridge University Hospitals, Portsmouth University Hospitals, and Imperial College, London. He holds an intercollegiate FRCS (ORL-HNS) from the Royal College of Surgeons of England, PhD from the Institute of Cancer Research, University of London, UK and MS (ENT) from the King George's Medical University, India. He is a dedicated Head neck and ENT surgeon, and has a unique blend of high quality clinical and research experience. His areas of interest are minimally invasive head neck, thyroid and parathyroid surgery, HPV related head neck cancers and outcome research. To date he has published 80 scientific papers in peer-reviewed indexed journals, 21 chapters (including one in upcoming edition of Scott-Brown's Otolaryngology: Head and Neck Surgery) and edited one head neck Surgery book. He has also served on the editorial board of 6 specialty journals and has been scientific reviewer for 35 peer-reviewed indexed journals including BMJ, Cancer, Head Neck, Oral oncology, Surgical.