Pathology of Female Cancers. Precursor and Early-Stage Breast, Ovarian and Uterine Carcinomas

New strategies for diagnosis of squamous intraepithelial neoplasia of the uterine cervix.- Adenocarcinoma and its precursor of the uterine cervix: current concept.- Heterogeneity of the precursor lesions of endometrial carcinoma, according to the histologic subtype.- Current concept of precancerous and early stage of serous ovarian carcinoma.- Ovarian carcinomas associated with endometriosis.- Problems with the histological diagnosis of epithelial borderline tumors of the ovary.- Development of breast carcinoma in relation to the intrinsic subtype.- Risk assessments of breast cancer occurrence, by morphological and molecular approach.

This book focuses on precursor lesions, borderline lesions, and early carcinomas of female-specific organs from the standpoint of pathology. In 2012, WHO Classification of Tumours of the Breast was revised and subsequently, in 2014, the WHO Classification of Tumours of Female Reproductive Organs was revised. In these latest versions, several new concepts are addressed that were not described in the previous editions, and many of them are related to the awareness of the specific pathogenesis of tumors in female patients. Although some of these issues are still controversial, several paradigm shifts should be understood by medical scientists. Thus researchers, diagnostic pathologists, and clinicians must share current information about what is taking place in the field and what the next issue to resolve is.

This volume greatly broadens the reader's understanding of the new concepts and paradigm shifts, as it includes information on how to diagnose and make differential diagnoses on a practical basis and also provides a thorough explanation of the molecular-clinicopathologic basis of the new concepts. The book thus benefits gynecologists, breast surgeons, gynecologic-medical oncologists, and cytotechnologists.

Dr. Takuya Moriya, MD, Professor. Department of Pathology, Kawasaki Medical School