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Tumor-Associated Fibroblasts and Their Matrix. Tumor Stroma (The Tumor Microenvironment, Vol. 4)
Mueller, M. — Fusenig, N.
1ª Edición Septiembre 2011
Inglés
Tapa dura
580 pags
1700 gr
null x null x null cm
ISBN 9789400706583
Editorial SPRINGER
ABOUT THIS BOOK
During the last 20 years it has become increasingly clear that the tumor micro-environment,
the tumor stroma with its cellular end extracellular components, plays an crucial
role in regulating tumor growth and progression. This book on “Tumor-associated
fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment”
is the first comprehensive discussion of these two main players of the tumor
microenvironment. The best experts in this new area of tumor research and therapy
review the role of these major components in the tumor stroma in the process
of tumor development and progression. They discuss their interaction with other
players such as blood vessels and immune cells, and show novel perspectives
for tumor therapy. This compilation of excellent contributions of the best known
experts in this important field in cancer research and therapy is a must for
all scientists engaged in basic and clinical research. Increasing evidence of
successful targeting of both cellular and matrix components in tumor therapy
renders this book of particular interest for scientists engaged in pharmaceutical
industry searching for new components for cancer therapy.
Content Level » Research
Keywords » cancer associated fibroblasts - novel targets for tumor therapy - tumor microenvironment - tumor specific ECM - tumor-stroma interactions
Related subjects » Biomedical Sciences - Cancer Research - Oncology & Hematology
TABLE OF CONTENTS
Preface. I. Overview. 1.Critical roles of stromal fibroblasts in the cancer microenvironments.II. Stromal Cell Diversity. 2. Functional diversity of fibroblasts. 3.The role of the myofibroblast in fibrosis and cancer progression. 4.The role of myofibroblasts in communicating tumor ecosystems. 5.Tumor vessel associated pericytes . 6.The role of Cancer-Associated Adipocytes (CAA) in the dynamic interaction between the tumor and the host.III.The Tumor ECM. 7. Hyaluronan: a key microenvironmental mediator of tumor-stroma cell interaction. 8.Tenascins. 9. Fibulins and their role in the ECM. 10.Tumor fibroblast associated metalloportease. IV. Tumor modulating-fibroblast interactions. 11.Multiple fibroblast phenotypes in cancer patients: heterogeneity in expression of migration stimulating factor. 12.TGF-ß Signaling in fibroblasts regulated tumor initiation and progression in adjacent epithelia. 13. SDF-1 rich in tumour microenvironment provides a niche for carcinoma cells. 14.Role of PDGF in tumor stroma interactions. 15. Radiation-induced microenvironments and their role in carcinogenesis. V. Tumor-modulating ECM interactions. 16. The extracellular matrix as a multivalent signaling scaffold that orchestrates tissue organization and function. 17. SPARC and the tumor micoenvironment. 18.Integrin-extracellular matrix Interaction. 19.The multifaceted role of cancer associated fibroblasts in tumor progression. VI. Therapeutic application/targeting. 20.Cancer Associated fibroblasts as therapeutic target. 21. Targeting Tumor Associated Fibroblasts and Chemotherapy. 22. Antibody-based targeting of tumor vasculature and stroma.
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