Meniere's Disease and Inner Ear Disorders. Update 2015

Preface

Cause, Pathogenesis and Symptoms of Ménière's Disease
Michael M. Paparella, Sebahattin Cureoglu

Pathology

Ménière's disease: histopathological analysis, novel ultrastructural, molecular and MRI findings
Gail Ishiyama, Ivan A. Lopez, Ali R. Sepahdari, Akira Ishiyama
The utriculo-endolymphatic (Bast) valve – Clinical significance
A. Belal

Pathways to the inner ear

Gentamicin distribution in the ear following local applications
A.N. Salt, J.J. Hartsock, R.M. Gill, E. King, B. Kraus, S.K. Plontke
Drug delivery via the oval window
Stephen J. O’Leary, Elisha B. King, James B. Fallon, Dan J. Brown, Alec N. Salt

Endolymphatic SAC

A new murine model for Ménière's disease ‒ Vasopressin-induced endolymphatic hydrops
Masaya Takumida, Yoshiaki Katagiri, Matti Anniko
Ion transport in endolymphatic sac epithelial cells on the basis of experimental animal researches
Nozomu Mori, Takenori Miyashita, Ai Matsubara, Ryuhei Inamoto

Audiological issues

On the role of depletive tests: A review analysis
Simonetta Monini, Edoardo Covelli, Silvia Tarentini, Vania Marrone, Maurizio Barbara
Kinesiology taping and kinetic training in rehabilitation of somatosensory vertigo
Katarzyna Pawlak-Osińska, Henryk Kaźmierczak, Katarzyna Kulczyńska
The usefulness of OPK parameters analysis for saccadic and smooth pursuit disturbances interpretation
Henryk Kaźmierczak, Katarzyna Pawlak-Osińska
Effects of bodytilt on multifrequency admittance tympanometry
V. Franco-Vidal, D. Bonnard, J. Nodimar, V. Darrouzet
Otoacoustic emissions in sudden sensorineural hearing loss
Avi Shupak, Reem Zeidan, Rafael Shemesh
A comparison of ECochG, VEMP, VNG and rotary chair results in patients diagnosed with Ménière's disease
John A. Ferraro, Pamela Svitak
Electrocochleography and cervical vestibular evoked myogenic potential test in Ménière's disease
Sasan Dabiri Satri, Nasrin Yazdani, Payam Abolhasani, Behrouz Amirzargar, Nima Rezazadeh
Predictive value of ECochG in offspring/siblings of individuals with Ménière's disease
John A. Ferraro, Jonathan R. Wilson

Genetics/Proteomics

Knockdown of HES-1 and COUP-TFI using shRNA gives rise to new hair cells and supporting cells in organotypic culture of the organ of Corti
J. Oiticica, A.C. Batissoco, K. Lezirovitz, M.M. Bissoli, D.B. Zanatta, B.E. Strauss, R.C. Mingroni-Netto, R.F. Bento
A proteomics-based approach in Ménière's disease
Giuseppe Chiarella, Claudio Petrolo, Alfonso Scarpa, Giuliano Sequino, Giovanni Cuda, Ettore Cassandro
Role of oxidative stress in the cochlear damage in acquired sensorineural hearing loss
Anna R. Fetoni, Fabiola Paciello, Rolando Rolesi, Sara L.M. Eramo, Diana Troiani, Gaetano Paludetti

Vestibular issues

Ocular (oVEMP) and cervical (cVEMP) VEMPs in patients with ‘clinically certain’ Ménière's disease
Sarah-Anne Johnson, Greg A. O’Beirne, Emily Lin, John Gourley, Jeremy Hornibrook
Prevalence, associated symptoms and prophylactic medication effectiveness of vestibular migraine in an otolaryngology clinic
Angelique Van Ombergen, Vincent Van Rompaey, Paul H. Van de Heyning, Floris L. Wuyts
The mystery of vertigo solved! The interactive GPS system
Aziz Belal
Role of perineuronal nets in vestibular compensation
Federico Dagna, Andrea Albera, Daniela Carulli, Alessio Faralli, Ferdinando Rossi, Gian Piero Giordano, Roberto Albera
Improving diagnostics of patients with vestibular paroxysmia
Berina Ihtijarevic, Vincent Van Rompaey, Paul Van de Heyning, Floris Wuyts
Vestibular neuritis according to VHIT testings. Clinical entities and prognostic factors
Romain Glatre, Charlotte Hautefort, Benjamin Verillaud, Christelle Domange, Philippe Herman, Romain Kania
Imaging Imaging of endolymphatic space in patients with Ménière's disease and non-otological diseases
Tadao Yoshida, Michihiko Sone, Kyoko Morimoto, Shinji Naganawa, Tsutomu Nakashima
Endolymphatic hydrops in patients with unilateral and bilateral Ménière's disease
Kyoko Morimoto, Tadao Yoshida, Michihiko Sone, Masaaki Teranishi, Shinji Naganawa, Saiko Sugiura, Tsutomu Nakashima
MRI evaluation of endolymphatic hydrops and clinical application for surgical management
Michihiko Sone, Tadao Yoshida, Tohru Mukaida, Masaaki Teranishi, Tsutomu Nakashima, Shinji Naganawa
MRI inner ear imaging and tone burst electrocochleography in the diagnosis of Ménière's disease
Jeremy Hornibrook, Edward Flook, Sam Greig, Melissa Babbage, Tony Goh, Mark Coates, Rachel Care, Philip Bird
MR imaging of inner ear endo-peri-lymphatic spaces at 3 Tesla after intratympanic contrast agent administration in definite Ménière's disease
S. Salice, A. Tartaro, M. Colasurdo, G. Filograna Pignatelli, A. Pacella, F. Cazzato, G. Neri
Understanding Ménière's disease (MD): The contribution of endolymphatic hydrops imaging (EHI)
Kumiko Y. Orimoto, Stephen J. O’Leary
The relationship between perilymph and cerebrospinal fluids in Ménière's disease: New findings in MRI after intratympanic administration of gadolinium
Giampiero Neri, Fiorella Cazzato, Andrea Di Tano, Alessandro Pacella, Giulio R. Filograna Pignatelli, Simone Salice, Armando Tartaro

Dehiscence syndrome

Migraine headache and the migraine variants of hemiplegic migraine, ocular migraine and vestibular migraine in otic capsule dehiscence syndrome: Outcomes after targeted repair
P. Ashley Wackym, Carey D. Balaban, Heather T. Mackay, Dale M. Carter
Superior canal dehiscence and ‘near-dehiscence’ syndrome: clinical and instrumental aspects
Andrea Castellucci, Gianluca Piras, Cristina Brandolini, Gian Gaetano Ferri, Giovanni Carlo Modugno, Antonio Pirodda
Retrospective cohort study on hearing outcome after transmastoid plugging in superior semicircular canal dehiscence syndrome: Safe and effective strategy in SSCD syndrome
Gilles Van Haesendonck, Paul Van de Heyning, Vincent Van Rompaey
Transmastoid plugging of superior semicircular canal dehiscence: the subarcuate canal on HR-CT is a useful surgical landmark
Th. Somers, L. Rotteveel, B. de Foer, J. van Dinther, A. Zarowski, R. van Spauwen, E. Offeciers

Clinical issues

Cerebral venous insufficiency in Ménière's disease
Roberto Filipo, F. Ciciarello, Giuseppe Attanasio, Patrizia Mancini, Edoardo Covelli, L. Agati, F. Fedele, Marika Viccaro
Ménière's disease symptomatology in relation to the AAO-HNS 1995 Guidelines
Roberto Albera, Claudia Cassandro, Andrea Albera, Andrea Canale, Jacopo Colombini, Carmine F. Gervasio
Cervical specific protocol and results for 300 Ménière's patients followed for a minimum of five years
Michael T. Burcon
Epidemiological characteristics of Ménière's disease in Japan: An update
Hideo Shojaku, Yukio Watanabe, Hiromasa Takakura, Masahiro Tsubota, Michiro Fujisaka, Mamoru Suzuki, Noriaki Takeda
Idiopathic acute labyrinthine diseases and Ménière's disease: The necessity of a multidisciplinary approach
Antonio Pirodda, Cristina Brandolini, C. Borghi

Treatment

Current status of the treatment procedure for the patients with Ménière's disease in Japan ‒ Unique treatment methods in Japan
Izumi Koizuka
Antisecretory factor and medical food – Novel therapy concepts
Jan G. Bruhn
Antisecretory factor-inducing therapy improves patient-reported functional levels in Ménière's disease
Samuel C. Leong, Surya Narayan, Tristram H. Lesser
SPC-Flakes® in the prophylaxis of Ménière's disease
Roberto Teggi, Vincenzo Marcelli
Ménière's disease patients in the acute stage
Augusto P. Casani, Niccolò Cerchiai, Elena Navari
Ménière's disease patients in the rehabilitative stage
Michel Lacour, Laurence Bernard-Demanze

Intratympanic treatment

Fifteen years of intratympanic pressure treatment for disabling Ménière's disease
Maurizio Barbara, Edoardo Covelli, Anna Teresa Benincasa, Luigi Volpini, Simonetta Monini
A study for local treatment using three different polymers aimed for middle ear administration
Cecillia Engmér-Berglin, Pernilla Videhult-Pierre, Andreas Ekborn, T. Bramer, Katarina Edsman, Malou Hultcrantz, Göran Laurell
Intratympanic dexamethasome: potential in the prevention of cisplatin ototoxicity
Avi Shupak, Tal Marshak, Levana Levi, Mariana Steiner
Intratympanic dexamethasone and gentamicin in the treatment of disabling vertigo in Ménière's disease
Rosemary B. Ojo, Julie A. Daugherty, Jack J. Wazen, Carmelo Ortega, Karen P. Draper, Joanna M. Tagarelli, Jack H. Thompson
Intratympanic or transtympanic drug therapy?
Aziz Belal

Surgery

Sac surgery for treatment of Ménière's disease
Ricardo F. Bento
Osteoplastic refinement in endolymphatic sac surgery
Randall A. Bly, Larry G. Duckert

Cochlear and vestibular implant

Vestibular implant for sensory restoration – candidacy and epidemiology
Bryan K. Ward, Daniel Q. Sun, Charles C. Della Santina
Cochlear implant and Ménière's disease: vestibular and auditory function
Raquel Manrique-Huarte, D. Calavia, Nicolas Pérez-Fernández, I. Ruiz-Erenchun, M.V. Ucar, Manuel Manrique
Cochlear implant in Meniere’s patients with asymmetric hearing loss
Domenico Cuda, Alessandra Murri
Spatial hearing improvement and long-term suppressive effect on tinnitus after cochlear implantation in single-sided-deaf patients with and without Ménière's disease
Vincent Van Rompaey, Griet Mertens, Paul Van de Heyning
Vestibular function before and after cochlear implantation in patients with post-lingual deafness: A prospective, observational study
Patricia A. Abramides, Roseli S.M Bittar, Robinson K. Tsuji, Ricardo F. Bento

Index of Authors

This book contains a collection of contributions that were delivered at the VII International Symposium on Ménière's disease and Inner Ear Disorders, held in Rome on October 17 to 20, 2015, and that were addressing many of the known, but also some of the unknown aspects of this inner ear disorder. Among them, a particular interest has been solicited by the genetic issue involving the inner ear in general and that will surely represent in the future one of the new pathogenetic and diagnostic lines to pursue for the study of the Ménière's population. A great impact is also foreseen by the routine application of specifically-designed imaging procedures that would enable to confirm the presence of endolymphatic hydrops as the real pathognomonic finding of the disease, and to follow-up the affected subjects during its clinical course, along with the role played by the different therapeutical approaches for it. The treatment of Ménière's disease seems also to have taken a straightforward direction towards the intratympanic delivery of drugs, where steroids appear to be promising molecules in this regard, without running particular risks for an additional inner ear damage, as it could be possible when ototoxic molecules are used.

Preface

For a mono-thematic meeting that gathers all the experts in the field every five years, one would expect to find many novelties and clarifications that had the right time to develop and to be validated. We all know that this would be unlikely to occur for Ménière's disease, one of the most intriguing, somewhat frustrating pathologies that, over more than 150 years since its first description, has kept scientists and dedicated professionals busy for any development that would be helpful for curing our affected patients.

This book contains a collection of contributions that were delivered at the VII International Symposium on Ménière's disease and Inner Ear Disorders, held in Rome on October 17 to 20, 2015, and that were addressing many of the known, but also some of the unknown aspects of this inner ear disorder. Among them, a particular interest has been solicited by the genetic issue involving the inner ear in general and that will surely represent in the future one of the new pathogenetic and diagnostic lines to pursue for the study of the Ménière population. A great impact is also foreseen by the routine application of specifically-designed imaging procedures that would enable to confirm the presence of endolymphatic hydrops as the real pathognomonic finding of the disease, and to follow-up the affected subjects during its clinical course, along with the role played by the different therapeutical approaches for it. The treatment of Ménière's disease seems also to have taken a straightforward direction towards the intratympanic delivery of drugs, where steroids appear to be promising molecules in this regard, without running particular risks for an additional inner ear damage, as it could be possible when ototoxic molecules are used.

Noteworthy is also the possibility for a self-administered local pressure treatment to positively act on the disease, allowing to avoid to resort to any surgical procedure for its resolution. The final part of the contributions that have highlighted the Meeting, and consequently this book, is devoted to the rehabilitation of the affected population from the most frequent irreversible damage caused by a long-lasting disease, i.e., deafness. The proposal of cochlear implantation, not only in the classical bilateral cases that would be rare for this disease, but also for the unilateral forms related to a single-sided deafness, is clearly seen as a promising tool to apply for restoration of the binaural auditory function, a problem that, for many years, has been left neglected and untreated.

A real novelty for this monothematic Meeting is represented by the report of a possible vestibular prosthesis that would enable mostly the bilaterally-impaired subjects to restore their balance disorder.

In summary, with all the limitations that a book containing contributions from a Meeting nowadays carries in term of scientific impact, it is the editor’s wish to promote it so as it could serve, in analogy with the publications of the previous Meetings, as a guide for the young colleagues who wish to get knowledge of Ménière's disease, as a cue for the development of new research lines, or – at least – as a memory of those fascinating days spent in the Eternal City to place on your crowded, hopefully not dusty, shelf. Prof.

Dr. Maurizio Barbara
President of the VII International Symposium