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A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
Borea, Pier Andrea
1ª Edición Enero 2010
Inglés
Tapa dura
322 pags
1000 gr
null x null x null cm
ISBN 9789048131433
Editorial SPRINGER
This Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death.
The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on:
- A3 Adenosine Receptor signal transduction
- Adenosine Receptor medicinal chemistry
- Effects and therapeutic applications of Adenosine Receptors on tissues and organs
- Adenosine Receptors and inflammatory and auto-immune diseases
- Adenosine Receptors and cancer
The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.
Written for: Professional/practitioner
Table of contents
PREFACE.- Pier Andrea Borea.- INTRODUCTION´.- From hypertension (+) to
asthma: interactions with the adenosine A3 receptor from a personal perspective
(John Fozard).- SECTION: PHYSICO- CHEMICAL PROPERTIES AND MOLECULAR BIOLOGY.-
Thermodynamic analysis in drug-receptor binding: the A3 adenosine receptor (Pier
Andrea Borea, Stefania Gessi, Stefania Merighi and Katia Varani).- Pharmacology
and molecular biology of A3 adenosine receptors (Karl-Norbert Klotz).- SECTION:
SIGNAL TRANSDUCTION.- Regulation of second messenger systems and intracellular
pathways (Stefania Merighi, Carolina Simioni, Rob Lane and Adriaan P. IJzerman.-
Desensitisation in A3 adenosine receptor regulation: physiopathological implications
(M. Letizia Trincavelli, Osele Ciampi and Claudia Martini).- SECTION: MEDICINAL
CHEMISTRY.- 6. A3 receptor agonists: history and future perspectives (Kenneth
A. Jacobson, Zhan-Guo Gao, Dilip K. Tosh, Gangadhar J. Sanjayan and Sonia de
Castro).- 7. A3 adenosine receptor antagonists: history and future perspectives
(Pier Giovanni Baraldi, Romeo Romagnoli, Giulia Saponaro, Stefania Baraldi,
Mojgan Aghazadeh Tabrizi and Delia Preti).- 8. Molecular modeling and re-engineering
of A3 adenosine receptors (Stefano Moro, Erika Morizzo and Kenneth A. Jacobson).-
SECTION: EFFECTS ON TISSUES AND ORGANS AND THERAPEUTIC APPLICATIONS.- 9. Adenosine
A3 receptor signaling in the central nervous system (Felicita Pedata, Anna Maria
Pugliese, Ana M. Sebastião and Joaquim A. Ribeiro).- 10. Cardiovascular
biology of the A3 adenosine receptor (John P. Headrick, Jason N. Peart, Tina
C. Wan, Wai-Meng Kwok and John A. Auchampach).- 11. A3 adenosine receptor in
the pulmonary system (Yifat Klein and Idit Matot).- 12. A3 adenosine receptor
regulation of cells of the immune system and modulation of inflammation (Stefania
Gessi, Valeria Sacchetto, Eleonora Fogli and John Fozard).- 13. Adenosine A3
receptors in muscle protection (Bruce T. Liang, Maria Urso, Edward Zambraski
and Kenneth A. Jacobson).- 14. A3 adenosine receptors, HIF-1 modulation and
atherosclerosis (Stefania Gessi, Stephen MacLennan, Edward Leung and Pier Andrea
Borea).- SECTION: INFLAMMATORY AND AUTO-IMMUNE DISEASES.- 15. Rheumatoid arthritis:
history, molecular mechanisms and therapeutic applications (Pnina Fishman and
Sara Bar-Yehuda).- SECTION: CANCER.- 16. Agonists and antagonists: molecular
mechanisms and therapeutic applications (Pnina Fishman, Sara Bar-Yehuda, Katia
Varani, Stefania Gessi, Stefania Merighi and Pier Andrea Borea).
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