Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells.
The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer.
The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer.
The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis.
- Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process
- Provides a comprehensive summary of current research in this ground breaking area
- Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise
- Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area
Written for: Libraries, medical and scientific research workers, oncologists, surgeons, students (undergraduate and postgraduate students in cancer biology, molecular biology, cell biology, medicine and oncology), biotechnology companies, pharmaceutical companies
Table of contents
1. LYMPHANGIOGENESIS IN HEALTH AND DISEASE – AN OVERVIEW
Steven A. Stacker, Marc G. Achen, P. Haiko and K. Alitalo
2. INSIGHT INTO LYMPHATIC VASCULATURE DEVELOPMENT
Nicole C. Johnson and Guillermo Oliver
3. NEW ANIMAL MODELS OF LYMPHANGIOGENESIS
Benjamin M. Hogan and Stefan Schulte-Merker
4. MOLECULAR MECHANISMS OF LYMPH-NODE METASTASIS
Matthias Rinderknecht and Michael Detmar
5. THE CLINICAL SIGNIFICANCE OF LYMPH-NODE METASTASIS
Mark B. Faries and Donald L. Morton
6. CLINICOPATHOLOGICAL ANALYSIS OF LYMPHATIC VESSELS AND OF LYMPHANGIOGENESIS
IN HUMAN CANCER
Ilse Van der Auwera, Peter B Vermeulen and Luc Y Dirix
7. LYMPHANGIOGENESIS AND IMAGING OF THE LYMPHATICS IN CANCER
Baris Turkbey, Gregory Ravizzini, Peter L. Choyke, and Hisataka Kobayashi
Kuniaki Seyama, Toshio Kumasaka, Teruhiko Sato and Keiko Mitani
9. KAPOSI’S SARCOMA AND THE LYMPHATICS
Victoria Emuss and Chris Boshoff
10. LYMPHATIC PHYSIOLOGY AND FUNCTION IN HEALTHY TISSUE AND CANCER
Jacqueline D. Shields and Melody A. Swartz