Allergy Frontiers, Vol. 1: Epigenetics, Allergens and Risk Factors

About this book

This book summarizes the most current knowledge on allergic diseases from epidemiology to mechanisms, environmental and genetic factors that influence the development of allergy and asthma clinical aspects, recent therapeutic and preventive strategies. Comprising of 6 volumes with each volume dedicated to a specific aspect of allergic disease [Volume 1: Evolution of Allergy, Epigenetics and Phenotypes, Allergens and Risk factors; Volume 2: Classification and Pathomechanisms, Allergy and the Nervous system and Allergy and mucosal immunology; Volume 3: Clinical manifestation of allergic diseases; Volume 4: Diagnosis and DD of allergic diseases and Allergy and Asthma Education; Volume 5: Therapy and prevention of allergies and Special Considerations in Children, Elderly and Pregnancy; Volume 6: Future perspectives], it is well illustrated throughout with numerous schematic diagrams and colour illustrations, and will serve as a valuable tool of information for scientists and practical guide for clinicians working in the field of allergy, asthma and immunology.

Written for: Scientists, clinicians working in the field of allergy, asthma, and immunology

Keywords:

• Allergens
• Epigenetics and Phenotypes
• Risk factors

Table of contents

Part I Evolution of Allergy

1 The Allergy Epidemic: A Look into the Future .................................... 3
U. Wahn

2 Is the Prevalence of Allergy Continuously Increasing? ........................ 17
Carlos E. Baena-Cagnani, R. Maximiliano Gomez, and R.M. Gomez

3 Allergy: A Burden for the Patient and for the Society ......................... 33
Erkka Valovirta

Part II Epigenetics and Phenotypes

4 The Epidemiology of Asthma and Allergic Rhinitis ............................. 49
Deborah Jarvis, Seif Shaheen, and Peter Burney

5 Epidemiology of Pediatric Asthma ......................................................... 79
Gary W.K. Wong

6 Epidemiology of Occupational Asthma ................................................. 91
A. Newman Taylor and P. Cullman

7 Epidemiology of Asthma Mortality ........................................................ 107
Richard Beasley, Meme Wijesinghe, and Kyle Perrin

8 Epidemiology of Anaphylaxis ................................................................. 123
David J. Chinn and Aziz Sheikh

9 Epidemiology and Food Hypersensitivity in Children and Adults ............... 145
Morten Osterballe

10 Genetics of Asthma and Bronchial Hyperresponsiveness .................. 161
Matthew J. Rose-Zerilli, John W. Holloway,and Stephen T. Holgate

11 Genetics of Pediatric Asthma ................................................................ 189
Naomi Kondo, Eiko Matsui, Hideo Kaneko, Toshiyuki Fukao,Takahide Teramoto,
Zenichiro Kato, Hidenori Ohnishi, and Akane Nishimura

12 Genetic and Molecular Regulation of b2-Adrenergic Receptors .................. 205
Ian Sayers and Ian P. Hall

13 Genetics of Hypersensitivity .................................................................. 227
John W. Steinke

14 Functional Genomics of Allergic Diseases ........................................... 239
Donata Vercelli

15 Differential Genetic Markers for Aspirin Hypersensitivity ............... 253
Hae-Sim Park, Seung-Hyun Kim, Young-Min Ye, and Gyu-Young Hur

Part III Allergens

16 Molecular Biology of Allergens: Structure and Immune Recognition ............ 265
Martin D. Chapman, Anna Pomes, and Rob C. Aalberse

17 Role of Allergens in Airway Disease and Their Interaction with the Airway Epithelium ...... 291
Irene Heijink and Henk F. Kauffman

18 Sensitisation to Airborne Environmental Allergens:
What Do We Know and What are the Problems? .............................. 311
W.R. Thomas, W. Smith, T.K. Heinrich, and B.J. Hales

19 The Immunological Basis of the Hygiene Hypothesis ......................... 325
Petra Ina Pfefferle, Rene Teich, and Harald Renz

Part IV Risk Factors

20 Early Sensitization and Development of Allergic Airway Disease? Risk Factors and Predictors:
Is the Adult Responder Phenotype Determined during Early Childhood? .............................. 351
Susanne Halken and Arne Host

21 T Cell Responses to the Allergens and Association with Different
Wheezing Phenotypes in Children .............................. 371
Peter N. Le Souef

22 Indoor Air Pollution and Airway Disease ........................................... 387
Sara Maio, Marzia Simoni, Sandra Baldacci, Duane Sherrill, and Giovanni Viegi

23 From Epigenetics to Future Perspectives: Evolution of Allergy, Epigenetics and Phenotypes,
Allergens and Risk Factors .................................................................. 403
Eric Livingston and Neil C. Thomson

24 Socioeconomic Status and Asthma in Children .................................. 427
Edith Chen and Hannah M.C. Schreier

Index ................................................................................................................ 441