Colitis-Associated Cancer

Description

The purpose of this book is to review the latest topics concerning medical treatment of colitis-associated cancer (CAC). The number of patients with CAC is on the increase. In recent years, the diagnostic power of endoscopy and molecular pathology has also grown tremendously, as a result of which they now have a far greater influence on treatment of CAC. At the moment, appropriate monitoring programs for ulcerative colitis and Crohn’s disease remain uncertain. At the same time, the latest findings on DNA methylation and microRNAs hold the promise of making revolutionary changes in these areas. Moreover, recent drug advances in the treatment of inflammatory bowel diseases have changed surgical indications. On the other hand, the indication of mucosectomy on colorectal cancer in ulcerative colitis and prophylactic abdominoperineal resection for Crohn’s disease remain controversial. This book provides the latest information on the remaining issues of CAC from the viewpoint of expert surgeons.

Feature:

• Provides current information on and approaches to colitis-associated cancer
• Covers topics ranging from basic research to clinical studies
• Introduce the latest biomarker tools used in cancer diagnosis

Contents

1. Overview (Masato Kusunoki)

Part I. Clinical Features

2. Incidence and Risk factor (Koji Tanaka Mie University School of Medicine, Japan)
3. Prevention and Prognosis (Motoi Uchino, Hyogo medical College, Japan )

Part II. Diagnosis

4. Surveillance (Yoshiki Okita, Mie University School of Medicine, Japan)
5. DNA Methylation and MicroRNAs (Yuji Toiyama, Mie University School of Medicine, Japan)

Part III. Surgical Treatment

6. Total Colectomy for Ulcerative Colitis (Toshimitsu Araki, Mie University School of Medicine, Japan)
7. Abdominoperineal Resection for Crohn’s Disease (Hiroki Ikeuchi, Hyogo medical College, Japan)