Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias

Description

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer’s disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan.
The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.

Feature:

• Describes the latest modalities for diagnosis of Alzheimer’s disease and other dementias
• Provides information on handling and analyzing imaging data for dementia
• Includes routine imaging studies in the management of dementia

Contents

1.- Epidemiology of dementia in Japan
2.- Diagnostic criteria for Alzheimer's disease
3.- Pathology for Alzheimer's disease and other dementias
4.- Structural neuroimaging in Alzheimer's disease
5.- MRI diagnosis in other dementias
6.- Diffusion Tensor Imaging in dementia
7.- Arterial Spin Labeling in dementia
8.- Magnetic Resonance Spectroscopy in dementia
9.- Resting-state fMRI in dementia
10.- FDG-PET in Alzheimer's disease
11.- Amyloid PET in Alzheimer's disease
12.- Tau PET in neurodegenerative diseases manifesting dementia
13.- Bran perfusion SPECT in Alzheimer's disease
14.- Neuroimaging of dementia with Lewy bodies
15.- Neuroimaging of frontotemporal lobe degeneration
16.- Neuroimaging study of Alzheimer's disease in population-based cohort
17.- Handling of MRI data in a multi-center study
18.- Standardization and quality control of PET data in a multi-center study.

Authors

Hiroshi Matsuda
Integrative Brain Imaging Center, National Center of Neurology and Psychiatry
matsudah@ncnp.go.jp

Takashi Asada
Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba

Aya Midori Tokumaru
Department of Diagnostic Radiology, Tokyo Metropolitan Medical Centre of Gerontology