This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve.
With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells.
This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.
Table of Contents
Part I Neuroprotection for Glaucoma.- 1. Molecular Architecture of Glutamate Signaling Pathway in Glaucomatous Optic Neuropathy.- 2. Calcium and Calpain Activation.- 3. Classical Signaling Pathways.- 4. Antioxidative Treatment for Neuroprotection in Glaucoma.- 5. ER stress.- 6. Nitric Oxide Contributes to Retinal Ganglion Cell Survival Through Protein S-Nitrosylation after Optic Nerve Injury.- 7. Neurotrophic factors.- 8. RIP Kinase-Mediated Programmed Necrosis.- 9. Axonal Degeneration.- 10. Axonal Transport.- 11. Interaction Between RGC Bodies and Glia.- 12. Aquaporin in optic neuropathies.- 13. Microglia.- Part II Neuroprotection for Age-Related Macular Degeneration (AMD), Retinal Pigmentary Degeneration.- 14. Neuroprotection for Photoreceptors.- 15. Retinal Photooxidative Stress and Its Modifiers.- 16. Roles of the Retinal Pigment Epithelium in Neuroprotection.- 17. Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis; Implication of Light Exposure.- 18. Interaction Between Photoreceptors and RPEs.- Part III Neuroprotection for Other Retinal Diseases.- 19. Neuroprotection for Retinal Detachment.- 20. Neuroinflammation.- 21. Optic Neuritis.- 22. Neuroprotection by Endothelial Progenitor Cells for Retinal Degeneration.- 23. Optic Nerve Regeneration.
Dr. Toru Nakazawa, MD, PhD.
Department of Ophthalmology Tohoku University Graduate School of Medicine
1-1 Seiryo-cho Aoba-ku Sendai-shi Miyagi-ken 980-8574, Japan
Dr. Yasushi Kitaoka, MD, PhD.
Department of Ophthalmology, St. Marianna University School of Medicine
2-16-1 Sugao, Kawasaki-shi, Kanagawa 216-8511, Japan
Dr. Takayuki Harada, MD, PhD.
Visual Research Project Tokyo Metropolitan Institute of Medical Science
2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan