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Cannabinoids in Nature and Medicine
Lambert, Didier
1ª Edición Septiembre 2009
Inglés
Tapa dura
356 pags
1000 gr
null x null x null cm
ISBN 9783906390567
Editorial WILEY
LIBRO IMPRESO
-5%
191,63 €182,05 €IVA incluido
184,26 €175,05 €IVA no incluido
Recíbelo en un plazo de
2 - 3 semanas
Description
Originally a special issue of Chemistry & Biodiversity, the first part
of this volume focuses on the plant Cannabis sativa, its active ingredients,
and the discovery of cannabinoid receptors as well as the therapeutic applications
of activating, or blocking, the receptors. Following an overview of the plant,
its medicinal uses, and its preparations, further chapters cover biosynthetic
pathways, pharmacological properties, cannabis-based medicine, toxicology, cannabis
prohibition and clinical situations where blocking the cannabinoid receptors
might be beneficial.
The second part covers the journey from humans to plants, analyzing anandamide,
as well as other endocannabinoids and endocannabinoid congeners, biosynthetic
pathways, current knowledge of FAAH-1, FAAH-2, monoglyceride lipase and NAAA,
concluding with new areas of research.
Table of Contents
1. Cannabis and Endocannabinoids: "The Old Man and the Teenagers"
(D. M. Lambert)
PART 1. The Phytocannabinoids: The Long Journey from the Plant to the Humans
2. History of Cannabis and Its Preparations in Saga, Science, and Sobriquet
(E. B. Russo)
3. Phytocannabinoids in Cannabis sativa: Recent Studies on Biosynthetic Enzymes
(F. Taura, S. Sirikantaramas, Y. Shoyama, Y. Shoyama, S. Morimoto)
4. On the Pharmacological Properties of delta9-Tetrahydrocannabinol (THC) (B.
Costa)
5. Cannabidiol - Recent Advances (R. Mechoulam, M. Peters, E. Murillo-Rodriguez,
L. O. Hanus)
6. From Active Ingredients to the Discovery of the Targets: The Cannabinoid
Receptors (K. Mackie)
7. Medicinal Chemistry Endeavors around the Phytocannabinoids (E. Stern, D.
M. Lambert)
8. Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex,
a Cannabis-Based Medicine (E. B. Russo, G. W. Guy, P. J. Robson)
9. The Toxicology of Cannabis and Cannabis Prohibition (F. Grotenhermen)
10. Human Cannabinoid Pharmacokinetics (M. A. Huestis)
11. Blocking the Cannabinoid Receptors: Drug Candidates and Therapeutic Promises
(G. G. Muccioli)
PART 2. The Endocannabinoid System: The Short Journey from the Humans to the
Plants
12. Discovery and Isolation of Anandamide and Other Endocannabinoids (L. O.
Hanus)
13. Biosynthetic Pathways of the Endocannabinoid Anandamide (Y. Okamoto, J.
Wang, J. Morishita, N. Ueda)
14. The Multiple Pathways of Endocannabinoid Metabolism: A Zoom Out (S. Vandevoorde,
D. M. Lambert)
15. Fatty Acid Amide Hydrolase: From Characterization to Therapeutics (G. Labar,
C. Michaux)
16. Monoglyceride Lipase as an Enzyme Hydrolyzing 2-Arachidonoylglycerol (S.
M. Saario, J. T. Laitinen)
17. The N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) (K. Tsuboi, N. Takezaki,
N. Ueda)
18. Genetic Polymorphisms of the Endocannabinoid System (A. G. Norrod, R. A.
Puffenbarger)
19. The N-Acylethanolamine-Mediated Regulatory Pathway in Plants (A. Kilaru,
E. B. Blancaflor, B. J. Venables, S. Tripathy, K. S. Mysore, K. D. Chapman)
20. Index
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