There is a growing body of experimental and clinical data to suggest that the
organs of the digestive system may be subjected to considerable oxidative stress
associated with acute and chronic inflammation. Although inflammation and ischemia
play a key role in producing oxygen-derived free radicals in the digestive tract,
the contribution of other factors, such as transition metal imbalances, lipid
and glucose metabolic disturbance, and the interaction with gaseous molecules
including nitric oxide and carbon monoxide, has also been suggested. Recent
studies have demonstrated that several biomarkers indicating oxidative stress-mediated
damage may help in monitoring the degree of disease and planning the design
of new therapeutic strategies. In addition, recent advances in ‘omics’
research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough
in the field of gastroenterology and hepatology: Several molecular targets for
oxidative stress have been presented by the ‘omics’.
This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology.
Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.