Asthma, allergy and chronic obstructive lung disease are common throughout
the world and are increasing in incidence, particularly in the developing world.
This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors.
Up to date and comprehensive, this book will be of particular relevance to
those working in the pharmaceutical industry (in preclinical research and clinical
development), to academic researchers in the field of respiratory medicine,
and to respiratory health care specialists.
New drugs and targets for asthma and COPD
Hansel, T.T. ; Barnes, P.J.
27 Indacaterol: A new once-daily long-acting ß2-adrenoceptor agonist (LABA)
Beier, J. ; Trifilieff, A. ; Higgins, M.
33 Aclidinium bromide, a novel long-acting muscarinic antagonist (LAMA)
Gavaldà, A. ; Garcia-Gil, E.
39 Dual-pharmacology bronchodilators for the treatment of COPD
Jacobsen, J.R. ; Aiyar, J. ; Hegde, S. ; Hughes, A.D. ; Mammen, M.
IgE- and epithelial-directed approaches
49 IgE-directed approaches: A general strategy for the treatment of atopic diseases
55 Therapy directed against thymic stromal lymphopoietin (TSLP)
T-cell co-stimulator blockade
63 ICOS and B7RP-1: Novel targets for monoclonal antibodies
Carlesso, G. ; Coyle, A.J. ; Herbst, R.
Pattern recognition receptors
69 Toll-like receptor 2 as therapeutic target in lung disease
Mitchell, J.A. ; Sorrentino, R. ; Cartwright, N. ; Paul-Clark, M.
73 Toll-like receptor 3
Carty, M. ; Bowie, A.
81 Toll-like receptor 4
87 Toll-like receptor 7 and 8 agonists
95 Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy
Kline, J.N. ; Krieg, A.M.
103 IL-5-directed approaches in the treatment of eosinophil-driven disease
Marshall, R. ; Faiferman, I.
109 Monoclonal antibody therapy directed against interleukin-5 receptor a: MEDI-563
Kolbeck, R. ; Koike, M. ; Kawasaki, K. ; Iwashita, K. ; Spitalny, G.L. ; Hanai, N. ; Kiener, P.A. ; Gossage, D. ; Molfino, N.A. ; Coyle, A.J.
115 IL-4- and IL-13-directed approaches
Borish, L. ; Steinke, J.W. ; Kasaian, M. ; Goldman, S.J.
Hansel TT, Barnes PJ (eds): New Drugs and Targets for Asthma and COPD. Prog Respir Res. Basel, Karger 2010, vol 39, pp 115–121
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123 Aerovant (recombinant human interleukin-4 variant)
Longphre, M.V. ; Fuller, R.W.
127 An anti-interleukin-13 receptor a1 antibody for the treatment of asthma
Fuentes, M.E. ; Dabbagh, K.
131 Interleukin-7-directed approaches
Shamim, Z. ; Müller, K. ; Ryder, L.P.
137 Monoclonal antibody therapy directed against interleukin-9: MEDI-528
Humbles, A.A. ; Reed, J.L. ; Parker, J. ; Kiener, P.A. ; Molfino, N.A. ; Kolbeck, R. ; Coyle, A.J.
141 Targeting interleukin-17 in the lungs
Ivanov, S. ; Lindén, A.
153 Chemokine CCR3 antagonists
Bahl, A. ; Springthorpe, B. ; Riley, R.
Hansel TT, Barnes PJ (eds): New Drugs and Targets for Asthma and COPD. Prog Respir Res. Basel, Karger 2010, vol 39, pp 153–159
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161 Therapeutic potential of CCR4 antagonists
Hall, D. ; Ford, A. ; Hodgson, S.
169 Very late activation antigen-4 (VLA-4) antagonists
Vanderslice, P. ; Woodside, D.G.
175 Selectin antagonists and their potential impact for the treatment of inflammatory lung diseases
Aydt, E.M. ; Bock, D. ; Wolff, G.
Mediator receptor antagonists
187 Histamine H4 receptor antagonists
Dunford, P.J. ; Thurmond, R.L.
193 Antagonists of the prostaglandin D2 receptor CRTH2
Pettipher, R. ; Hansel, T.T.
201 5-Lipoxygenase inhibition
Masferrer, J.L. ; Wegner, C. ; Graneto, M.
207 Utility of cytosolic phospholipase A2a (cPLA2a) inhibitors in the treatment of asthma
Clark, J.D. ; Williams, C.M.M.
215 Antioxidant therapeutic strategies
Kirkham, P. ; Rahman, I.
Hansel TT, Barnes PJ (eds): New Drugs and Targets for Asthma and COPD. Prog Respir Res. Basel, Karger 2010, vol 39, pp 215–221
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225 Small-molecule neutrophil elastase inhibitors as therapies for respiratory disease
231 The role of MMP-9 and MMP-12 inhibitors in inflammation
Wong, S. ; Birrell, M.A. ; Belvisi, M.G.. ; Stenvall, K. ; Bertrand, C.P.
237 a1-Antitrypsin therapy
Barr, P.J. ; Pemberton, P.A.
Inhibitors of fibrosis and vessels
245 Proteinase-activated receptor-1 inhibitors
251 Integrin-mediated transforming growth factor-ß activation
Jenkins, G. ; Sheppard, D.
255 Small-molecule inhibitors of transforming growth factor-ß type I receptor kinase (ALK5)
Wong, D.H. ; Higgins, L.S.
261 Serum amyloid P: A novel antifibrotic agent with therapeutic potential
Lupher Jr., M.L. ; Willett, W.S.
Inhibitors of cell signaling and transcription
269 Phosphodiesterase type 4 (PDE4) inhibition: The search for effective therapy with minimal side effects
Yeadon, M. ; Clarke, N. ; Ward, J.
279 Therapy directed against c-kit (CD117) and PDGF transmembrane receptor tyrosine kinases
Walker, C. ; Rodman, D. ; Hansel, T.T.
283 Syk kinase inhibitors
Denyer, J. ; Patel, V.
289 Targeting protein kinase C-? for asthma
Chaudhary, D. ; Boschelli, D.H. ; Kasaian, M.T.
Hansel TT, Barnes PJ (eds): New Drugs and Targets for Asthma and COPD. Prog Respir Res. Basel, Karger 2010, vol 39, pp 289–293
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Nucleic acid therapy
297 A multitargeted antisense therapy directed at CCR3 and the common ß-chain of IL-3/IL-5/GM-CSF
Paquet, L. ; Renzi, P. ; Ferrari, N. ; Parry-Billings, M. ;
303 Author Index
304 Subject Index