This volume sets the stage for clinical experts working with diabetic patients
as well as for researchers by describing the clinical presentations of retinopathy
and their anatomical and functional correlates. It reviews currently available
experimental models in animals. The impact of retinal pericytes, neuroglia and,
specifically, Müller cells are discussed in detail. The volume addresses
a variety of current scientific discussions about mechanisms of damage such
as growth factors and the VEGF/PEDF balance in the diabetic eye, the ocular
renin-angiotensin system, and leukocyte interactions with the microvasculature
among others. Stem and progenitor cells in the retina are discussed as potential
directions for future investigation. The final chapters return to emerging clinical
aspects, including current approaches to retinopathy as a predictor of cardiovascular
risk and how knowledge can be translated from bench to bedside.
Bridging a widening gap in medical research between basic scientists, who may lose sight of the clinical presentations, and clinical researchers, who may grow unaware of the limits of experimental models, this volume serves as a reference platform for endocrinologists, diabetologists, ophthalmologists, as well as for scientists involved in clinical and basic research in diabetic retinopathy and other vascular complications of diabetes.