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Varicella-Zoster Virus (Current Topics in Microbiology and Immunology, Vol. 342)
Abendroth, A. — Moffat, J. — Arvin, A.
1ª Edición Junio 2010
Inglés
Tapa dura
360 pags
1000 gr
16 x 24 x 3 cm
ISBN 9783642127274
Editorial SPRINGER
About this book
Varicella-zoster virus is a common human pathogen that causes varicella (chickenpox),
establishes latency in sensory nerve ganglia and can reactivate many years later
as herpes zoster. Although the VZV genome is the smallest of the human herpesviruses,
VZV genes encode at least 70 proteins. Molecular epidemiologic approaches based
on genomic sequencing have documented the global distribution of VZV in distinct
clades that reflect patterns of human migration. Contemporary molecular methods
are making it possible to dissect how VZV gene products support the viral life
cycle, including those that are necessary for viral replication, virion assembly
and egress as well as those that permit take over of the host cell by modulating
cell cycle regulation, survival and intrinsic antiviral responses. Progress
is also being made in understanding the events in VZV pathogenesis and the viral
tropisms for keratinocytes, T cells, dendritic cells and neurons during primary
infection, latency and reactivation and the innate and adaptive host responses
that modulate these events. New insights about molecular virology and pathogenesis
have emerged from comparative studies of VZV and simian varicella virus. VZV
is the only human herpesvirus for which vaccines to prevent both primary and
recurrent infection are approved and VZV vaccines have had significant public
health benefits. These achievements and new directions that are unfolding are
described in this review of VZV basic and clinical research
Content Level » Research
Keywords » VZV ORF66 - VZV genome - VZV infection - VZV replication -
dendritic cells - herpes zoster - nosocomial spread - post-herpetic neuralgia
- simian varicella virus
Related subjects » Virology
Table of contents
The VZV Genome, Replication and Effects on Host Cell Cycle Regulation.- The
Varicella-Zoster Virus Genome.- VZV Molecular Epidemiology.- Roles of Cellular
Transcription Factors in VZV Replication.- Effects of varicella-zoster virus
on cell cycle regulatory pathways.- VZV Kinases.- VZV ORF66 protein kinase and
its relationship to alphaherpesvirus US3 kinases.- VZV ORF 47 serine protein
kinase and its viral substrates.- VZV Glycoproteins.- Overview of varicella-zoster
virus glycoproteins gC, gH and gL.- Analysis of the function of glycoproteins
E and I and their promoters during VZV replication in virto and in skin and
T cell xenografts in the SCID mouse model of VZV pathogenesis.- Varicella-zoster
virus glycoprotein M.- VZV Tropism for Cells of the Immune System and Skin.-
Varicella Zoster Virus Immune Evasion Strategies.- VZV Infection of Keratinocytes:
Production of Cell-Free Infectious Virions in vivo.- Varicella-Zoster Virus
T cell Tropism and the Pathogenesis of Skin Infection.- Experimental models
to study varicella zoster virus infection of neurons.- VZV Neurotropism, Latency
and Reactivation.- Molecular Characterization of Varicella Zoster Virus (VZV)
in Latently Infected Human Ganglia: Physical State and Abundance of VZV DNA,
Quantitation of Viral Transcripts and Detection of VZV-Specific Proteins.- Neurological
Disease Produced by Varicella Zoster Virus Reactivation without Rash.- VZV neurotropism
in SCID mouse-human DRG xenografts.- Rodent Models of Varicella-zoster virus
neurotropism.- Siminan Varicella Virus.- Simian Varicella Virus: Molecular Virology.-
Simian Varicella Virus Pathogenesis.- VZV Vaccines.- VZV Vaccine: Molecular
genetics.- VZV T Cell-Mediated Immunity.- Perspectives on Vaccines against Varicella-Zoster
Virus Infections.- Subject index
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