This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.
Content Level » Professional/practitioner
Keywords » Antibiotic use - MODS - Organ dysfunction - Sepsis - Severe infections in the ICU
Related subjects » Anesthesiology - Critical Care & Emergency Medicine - Internal Medicine
TABLE OF CONTENTS
Multi-organ dysfunction syndrome (MODS): what is new?- MODS scores. Which should I use?- Why guidelines require reform?- Collateral damage in septic shock management.- Is extravascular lung water required for management of pulmonary oedema in severe sepsis?- Biomarker monitoring helps in clinical decision making.- Monitoring myocardial dysfunction as part of sepsis management.- Lung in MODS.- Assessing renal dysfunction in septic patients.- ATB treatment in sepsis with MODS. New paradigms.- Importance of high creatinine clearance for ATB treatment in sepsis.- PIRO concept in 2010.- How do I adjust ATB daily dosage in patients with MODS? A pharmacist’s contribution.-
AUTHORS & EDITORS
Drs. Rello, Lipman and Lisboa participate in several critical care meetings with lectures on sepsis, antibiotic treatment and organgdysfunction. Every year they organize a meeting in Tarragona, Spain on the management of sepsis. In 2009 the focus was on PIRO, hence the book by Rello et al.: Management of Sepsis: the PIRO Approach. In 2010 the focus will be on MODS.