Post-Transplant Lymphoproliferative Disorders

About this book

Post-transplant lymphoproliferative disorders are a group of conditions that straddle the borders between infection and malignancy. They were very rare prior to the mid-1980s but now can be expected to develop in 1-10% of transplant recipients. While some cases are reversible with reduction in immunosuppression, more severe forms are indistinguishable from frank lymphomas.

This book sets out to cover in depth every aspect of these disorders, including both basic science and clinical topics. The epidemiology is reviewed, and careful attention is paid to the role of Epstein-Barr virus in their development. Clinical features are documented and clear guidance is provided on diagnosis, with thorough description of pathologic and imaging findings. Further chapters are devoted to treatment, prognosis, preventive and pre-emptive strategies, and organ-specific considerations.

The state-of-the-art information contained in this book will aid researchers as well as the many different professionals involved in caring for patients with post-transplant lymphoproliferative disorders. The comprehensive and detailed coverage will appeal to those who already have some expertise in the field, yet the book will also serve as an invaluable resource for beginners in transplantation.

Written for: All physicians involved with the treatment of transplant patients, especially nephrologists, oncologists, surgeons as well as PTLD researchers

Keywords:

Epstein-Barr virus
Kidney transplantation
Lymphoproliferative disease
Malignancy
Solid organ tranplantation

Table of contents

Introduction.- Historical Aspects of PTLD.- Epidemiology of PTLD.- Biology of Epstein-Barr virus and PTLD.- Epstein-Barr viral loads: Measurement and interpretation.- Clinical Features and Diagnostic Evaluation of PTLD.- Pathology of PTLD: Pathology.- Prognostic Factors for PTLD.- Treatment of PTLD.- Prevention/Pre-emptive therapy for PTLD.- Organ specific issues of PTLD: Kidney - Liver/Intestine - Heart/Lung - Hematopoietic/stem cell.- Research Priorities and Future Directions.