Lead-Seeking Approaches

About this book

Christopher A. Lipinski: Overview of Hit to Lead: The Medicinal Chemist’s Role from HTS Retest to Lead Optimization Hand Off
Jeff W. Paslay • John E. Morin • Richard K. Harrison: High Throughput Screening in the Twenty - First Century
Jack Andrew Bikker • Lakshmi S.Narasimhan: Lead Discovery Using Virtual Screening
Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug Design
Kevin D. Freeman-Cook • Daniel W. Kung: Hit Triage – Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery
John W. Ellingboe • Adam M. Gilbert: Lead Identification

Written for: Medicinal chemists working in chemistry, medicine, pharmacy and biology

Table of contents

Christopher A. Lipinski: Overview of hit to lead: the medicinal chemist’s role from HTS retest to lead optimization hand off.- Jeff W. Paslay; John E. Morin; Richard K. Harrison: High Throughput Screening in the 21st Century.- Jack Andrew Bikker; Lakshmi S.Narasimhan: Lead Discovery Using Virtual Screening.- Maurizio Pellecchia: NMR Spectroscopy in Fragment Based Drug Design.- Kevin D. Freeman-Cook; Daniel W. Kung: Hit Triage – Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery.- John W. Ellingboe; Adam M. Gilbert: Lead Identification.