Much anecdotal information has suggested an influence of psychology and the nervous system on immunity within the skin and the expression of inflammatory skin disorders. Recent years have seen an explosion of knowledge providing a scientific basis for important regulatory interactions between the nervous system, the endocrine system and the immune system within the skin. The results of recent investigations have important implications, not only for an understanding of cutaneous immunity, but also for the development of novel treatments for diseases involving abnormal inflammation or immune reactivity within the skin. This book provides a comprehensive and interdisciplinary review of the molecular biology, cell biology, biochemistry and clinical aspects of nervous system–immune system interactions within the skin. It includes contributions from leading world experts in these areas. The contents are relevant to both investigators and clinicians interested in the skin, its functions and its disorders.
Dermatologists, allergologists, immunologists, neurologists, psychologists and psychiatrists
Table of contents
Introduction.- Basic Neuroimmunology of the Skin.- Neuroanatomy of the Skin.- Neuroreceptors and Mediators.- Interaction of the Neuroimmune and Vascular Systems.- Immune Circuits of the Skin.- Modulation of Immune Cells by Products of Nerves.- Regulation of Immune Cells by POMC Peptides.- Regulation of Cutaneous Immunity by Catecholamines.- The Role of Neuropeptide Endopeptidases in Cutaneous Immunity.- Toll-Like Receptors: Role in Neurobiology.- Stress in Cutaneous Immunity.- Neuroendocrine Effects of Stress.- Stress and Cutaneous Immunity.- Effects of Stress on Inflammatory Skin Disease.- Photoneuroimmunology: Modulation of the Neuroimmune System by UV-Light.- Neurophysiology of Itch.- Autonomic Effects on the Skin.- Neurobiology of Hair, Sebaceous Glands, Eccrine/Apocrine Glands.- The Nervous System and the Pathophysiology of Skin Disorders.- Psoriasis.- Atopic Dermatitis.- Alopecia Areata.- Urticaria.- Acne Vulgaris and Rosacea.- Wound Healing.- Aging.- Index.