Drug Delivery in Oncology. from Basic Research to Cancer Therapy, Volume 1

Description

In this first authoritative overview on modern cancer chemotherapy 100 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field.

The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field.

By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

Table of contents

• PRINCIPLES OF TUMOR TARGETING
• Limits of Conventional Cancer Chemotherapy
• Pathophysiological and Vascular Characteristics of Tumors in Relation to Drug Delivery
• The EPR-Effect in Relation to Tumor Targeting
• Pharmacokinetics of Antibodies and Albumin: Implications for the Role of the MHC Receptor FcRn and T Cell Receptor for the Design of Drug Delivery Systems
• Development of Cancer Targeting Ligands and Ligand-Drug Conjugates
• Two-Step Approaches to Cancer Therapy

• TUMOR IMAGING
• Imaging Techniques in Drug Development and Clinical Practice
• Magnetic Nanoparticles in MR Imaging and Drug Delivery
• Near Infrared Imaging
• Imaging Techniques for Cancer -
• From Microscopy to Quantum Dots and Nanoshells
• Preclinical and Clinical Tumor Imaging with PET and SPECT/CT

• MACROMOLECULAR DRUG DELIVERY SYSTEMS
• Antibody-Based Systems
• Empowered Antibodies for Cancer Therapy
• Vascular Targeting to Penetrate Solid Tumors
• Considerations of Linker Technologies
• Clinical Experience with Maytansine Antibody Conjugates
• Mylotarg and Beyond
• Antibodies for the Delivery of Radionuclides
• Bispecific Antibodies and Immune Therapy Targeting

• POLYMER-BASED SYSTEMS
• Design of Polymer-Drug Conjugates
• Dendritic Polymers as Drug Delivery Systems in Oncology
• Self-Immolative Systems
• Ligand-Assisted Targeting of Polymer Therapeutics
• Drug Conjugates with Poly(ethylene)glycole
• Thermally Responsive Polymers
• Polysaccharide-Based Drug Conjugates for Tumor Targeting
• Serum Proteins as Drug Carriers of Anticancer Agents
• Combination Therapy with Drug Polymer Conjugates
• Clinical Experience with Drug Polymer Conjugates

• NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS
• Nanocarriers as Delivery Systems
• The Development of Pegylated Liposomes
• Immunoliposomes
• Responsive Liposomes (for Solid Tumor Therapy)
• Liposomal Formulations for Optimized Combination Therapy

• POLYMER-BASED SYSTEMS
• Micellar Strcutures as Drug Delivery Systems
• Tailor-Made Hydrogels for Tumor Delivery
• pH-Triggered Micelles
• Albumin Nanoparticles
• Carbon Nanotubes

• LIGAND-BASED DRUG DELIVERY SYSTEMS
• Cell-Penetrating Peptides in Cancer Targeting
• Subcellular Targeting
• Targeting to Peptide Receptors
• Aptamer Conjugates
• Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors
• Drug Conjugates with Fatty Acids

• SPECIAL TOPICS
• RNA Drug Delivery Approaches
• Local Gene Delivery for Therapy of Solid Tumors
• RNA Delivery Using Viral Vectors
• Design of Targeted Protein Toxins
• CNS Drug Delivery
• Liver Tumor Targeting
• Drug Delivery in Photodynamic Therapy
• Tumor Targeting Strategies with Anticancer Platinum Complexes