Clinical Toxicological Analysis: Procedures, Results, Interpretation, 2 Vol. Set

Description

This first, complete reference on standardized methods for laboratory analysis is tailor-made for clinical toxicologists, containing all relevant data and protocols for routine and specialized laboratory analysis. All the procedures described conform to standards stipulated by the International Standards Organisation (ISO) and academic societies, such as the IUPAC and ICC.
Neatly divided into two volumes, the first deals with requirements for toxicological analyses, quality assessment, the evaluation of analytical results, forensic aspects, clinical chemistry and therapeutic drug monitoring, while the second contains detailed protocols for the analysis of toxicants.

A handy desktop reference for the practitioner.

Table of Contents

Preface
Introduction (W.R. Kulpmann)
Requirements for toxicological analyses (F. Degel)
General aspects
Materials for investigation (H.J. Gibitz, F. Pluisch)
Methods for clinical toxicological analysis (W.R. Kulpmann, D. Hannak, F. Degel, H. Kaferstein, H.H. Maurer, H.J. Gibitz , F. Pragst, H. Konig)
Practicability of clinical toxicological analyses (H.J. Gibitz)
Quality assurance (W.R. Kulpmann, L. von Meyer, M. Geldmacher-von Mallinckrodt)
Assessment of analytical results (W.R. Kulpmann, M. Geldmacher-von Mallinckrodt, J.Hallbach)
The analytical-toxicological report (J. Hallbach, M. Geldmacher-von Mallinckrodt, W.R. Kulpmann)
Medical interpretation (J. Hallbach, N. Felgenhauer, M. Geldmacher-von Mallinckrodt,
H.H. Maurer)
Forensic aspects (W.R. Kulpmann)
Strategy of clinical-toxicological investigations (J. Hallbach, W.R. Kulpmann, H.H. Maurer, F. Pragst, N. Felgenhauer)
Screening procedures for "General Unknown" analysis (F. Pragst, H.H. Maurer, J. Hallbach, W.R. Kulpmann, F. Degel, U. Staerk, M. Lappenberg-Pelzer)
Nonopioid analgesics and antirheumatics (H. Konig and J. Hallbach)
Analgesics: Opiates and opioids (H. Kaferstein, W.R. Kulpmann, G. Sticht, L. von Meyer, H. Konig, H. Schmoldt, F. Degel, T. Binscheck, J. Hallbach)
Antidysrhythmic agents (H. Konig, A. Schmoldt)
Anticonvulsants (D. Hannak, W.R. Kulpmann, J. Hallbach)
Anticoagulants (L. von Meyer, M. Geldmacher- von Mallinckrodt)
Bronchodilators (W.R. Kulpmann)
Calcium-channel blockers (J. Hallbach, A. Schmoldt)
Cardiac glycosides (J. Hallbach)
Hypnotics: Barbiturates (W.R. Kulpmann, A. Schmoldt)
Hypnotics and sedatives: Benzodiazepines (L. von Meyer;
A. Schmoldt, W.R. Kulpmann)
Hypnotics and sedatives (except for barbiturates and benzodiazepines) (H. Konig, H. Kaferstein, F. Pragst, H.J. Gibitz)
Neuroleptic drugs and antidepressants (F. Degel, W. Steimer, T. Grobosch, M. Geldmacher- von Mallinckrodt, H.-J. Birkhahn, D. Lampe, U. Demme, T. Grobosch)
?-Receptor blocking drugs (L. von Meyer, W.R. Kulpmann)
Drugs of abuse (G. Sticht, H. Kaferstein, L. von Meyer, J. Hallbach, Merckel, V. Auwarter, D. Simmert, F. Pragst, H. Konig, W.R. Kulpmann)
Solvents and inhalants (H.J. Gibitz , F. Degel, H. Desel, M. Geldmacher-von Mallinckrodt, C. Koppel)
Pesticides (M. Geldmacher-von Mallinckrodt, F. Degel, T. Daldrup, C. Koppel)
Antidiabetics (J. Hallbach and K. Rentsch)
Dyshemoglobins (H.J. Gibitz)
Various drugs and toxic agents (M. Geldmacher-von Mallinckrodt, H. Kaferstein, H. Konig, A. Scholer, T. Daldrup, F. Pragst, H.J. Gibitz, R. Aderjan)
Chemical warfare agents (M. Koller, L.Szinicz)
Biochemical investigations in toxicology (W.R. Kulpmann, P. Eyer, F. Worek)
Therapeutic drug monitoring (W.R. Kulpmann)
Poisonous plants (M. Geldmacher - von Mallinckrodt, L. von Meyer)
Poisonous mushrooms (F. Degel)
Venomous and poisonous animals (D. Mebs)
Appendix 1 Abbreviations
Appendix 2 Therapeutic and toxic concentrations of drugs and xenobiotics in plasma or serum
Appendix 3 BAT values
Appendix 4 Antidotes
Appendix 5 Poison Information Centres

Author Information

Wolf Külpmann heads the Department of Clinical Chemistry at the Medical University of Hannover (Germany), which is processing more than 4 million clinical analyses per year. One of his main interests is to improve the quality control of clinical analyses by developing standards and reference measurements for a variety of analytes. He is a member of the national (German Standards Institute, DIN), European (CEN) and international (ISO) medical standards institutions. He is also a member of the International Federation of Clinical Chemistry and of the joint IUPAC/ICC committee on nomenclature, properties and units.