Male Osteoporosis. Gender Differences in Pathophysiology, Clinical Aspects, Diagnosis and Treatment

Preface.- Introduction.- Introductory remarks: Gender differences in osteoporosis: from research to treatment.- Anatomy and histology of male skeletal tissue: gender differences - Physiology of bone mass acquisition and pathophysiology of bone mass loss: gender differences Epidemiology of male osteoporosis and fractures.- Economic and social impact of male osteoporosis and fractures.- Diagnosis of osteoporosis and fracture risk assessment: gender differences (anamnesis, algorithms, blood tests, DXA).- Male osteoporosis and imaging (QUS, CT, RM, xray).- Causes and pathophysiology of osteoporosis in men: Introduction: causes and risk factors for male osteoporosis.- Genetics of osteoporosis: gender differences.- Aging and bone loss.- Androgens and bone.- Estrogens and male osteoporosis.- Vitamin D and male osteoporosis.- Testicular function and skeletal alterations.- Endocrinological causes of male osteoporosis.- Osteoporosis in Klinefelter syndrome.- Nutritional disturbances and osteoporosis during puberty (anorexia, bulimia).- Lifestyle and osteoporosis risk in men (physical activity, diet, alcohol abuse).- Drug induced male osteoporosis.- Obesity and male osteoporosis: protective factor?.- HIV and osteoporosis.- Cardiovascular risk and osteoporosis: is there a link?.- Osteoporosis and hormonal therapy in prostate cancer.- Doping and skeletal alterations.- Sarcopenia-osteoporosis: the fragile man.- Prevention, screening and treatment: Prevention of male osteoporosis in the different ages.- Screening foroporosis in men: critical summary of international guidelines.- Androgen therapy.- Vitamin D supplementation.- Pharmacological therapy.- Femur fragility fracture in men and surgical therapy risks.- Rehabilitation therapy after surgery in osteoporotic patients.- Future research and clinical issues.

This book represents a comprehensive, clinically oriented text covering all aspects of male osteoporosis, from the basic concepts of bone physiology and regulation of bone remodeling in men, the causes and pathophysiological mechanisms responsible for the most frequent causes of osteoporosis, to diagnostic and screening protocols, as well as prevention and treatment approaches. It offers a broad overview of male osteoporosis by specialists involved in research and clinical practice and discusses the practical issues encountered.

Filling a gap in the literature, this volume is a valuable resource for general practitioners, clinical endocrinologists, geriatricians and experts in osteoporosis.

Alberto Ferlin has worked in the field of clinical endocrinology and andrology since 1995. He is an associate professor of endocrinology at the University of Brescia, Department of Clinical and Experimental Sciences, Unit of Endocrinology and previously has worked for 20 years at the University of Padova, Department of Medicine, Unit of Andrology and Reproductive Medicine. His principal research fields include: molecular biology and genetics of spermatogenesis and male infertility, cryptorchidism and testicular cancer; role of FSH in the regulation of spermatogenesis and therapy of male infertility; pharmacogenetics of male infertility; testicular expression profiles in male infertility; functional analysis of androgen receptor gene, INSL3 and Y chromosome genes; pre-implantation genetic diagnosis; sperm genetics; molecular and clinical aspects of Klinefelter syndrome; testis-bone cross-talk; systemic effect of INSL3; male hypogonadism and male osteoporosis. He participated in research programs at the University of Padova, Telethon, the Italian Ministry of University, Veneto Region, Italian Health Ministry and cooperated in European and non-European research projects. He is president of the Italian Society of Andrology and Medical Sexology for 2016-2018. He has been and invited speaker at more than 150 international congresses and national congresses and is the winner of 12 scientific awards. He is an associate editor for Human Reproduction, Andrology, and Frontiers in Endocrinology, and referee for many international scientific journals. He is the author of more than 300 publications.

Silvia Migliaccio has been active in the field of clinical endocrinology and nutrition since 1995. She is an associate professor of applied medical technical sciences at the University of "Foro Italico" of Rome, Department of Movement, Human and Health Sciences, Unit of Endocrinology. Her principal research fields include: molecular biology and clinical aspects of skeletal diseases, male and female osteoporosis, gender medicine; life-style and chronic diseases, adipose-bone-muscle tissues cross-talk; steroid receptor and intracellular signalling. She is editor of Multidisciplinary Approach to Obesity (Springer), and referee for many international scientific journals. She participated in research programs at the University of Foro Italico of Rome, Telethon, AIRC, Italian Ministry of University and collaborated in European and non-European research projects. She is also national secretary of the Italian Society of Food Sciences and has been an invited speaker at several international and national congresses. She is the author of more than 150 publications.