Neonatal Infections. Pathophysiology, Diagnosis, and Management

Early Onset Sepsis
Late Onset Sepsis
Necrotizing Enterocolitis
Candida
Neonatal conjunctivitis
Respiratory Viruses in the Neonatal Intensive Care Unit
Pathogenesis of congenital infections
Chagas disease
Cytomegalovirus infection
Enteroviruses
Hepatitis B in the Perinatal Period
Hepatitis C and Pregnancy
Neonatal Herpes Simplex Virus Infection
Management of HIV-exposed infants
Lymphocytic choriomeningitis virus
Malaria
Parvovirus
Rubella
Congenital Syphilis
Tick-borne infections
Toxoplasmosis
Tuberculosis in the Neonate
Varicella in the Peripartum Period
Zika virus
Infection Prevention
Outbreaks
Antibiotic stewardship
Immunizations in the Nursery

There are approximately 4 million newborns annually in the United States, including 400,000 infants born preterm. This care occurs in nurseries of all acuity levels, sizes, and regions across the country and is provided by a variety of providers, including pediatricians, family practice doctors, nurse practitioners, and physician assistants. The most common complication during the newborn period is suspected or proven infection - either those acquired during the delivery itself or before delivery in the womb. Indeed, 4 of the 8 most commonly-prescribed medications in newborns annually are antibiotics. Therefore, these providers must all be knowledgeable about the clinical presentation, epidemiology, and approach to diagnosis, treatment and prevention of neonatal infections. However, many of these nurseries do not have convenient access to pediatric infectious disease consultation or support, and would benefit from a convenient reference guide.

This book effectively and succinctly covers the pathophysiology, epidemiology, clinical presentation, approach to diagnosis and treatment, and important aspects of preventative care for the most frequently encountered neonatal and congenital infections. The first section discusses common neonatal infections (i.e., those acquired during or after delivery), including sepsis, meningitis, pneumonia, and other focal infections. The second section covers the most frequently encountered congenital infections (i.e., those acquired via the placenta while the fetus is still in-utero). Finally, the concluding section discusses the basics of infection prevention in the nursery setting, including general principles of infection prevention, how to apply those principles to families, and how to manage a suspected outbreak of infection within a nursery.

This book is a unique contribution to the field. Existing texts such as the AAP Red Book fold neonatal infections in within chapters on a given pathogen, but the information is difficult to find and access quickly. By covering neonatal and congenital infections thoroughly while still keeping each section clear and concise, this Handbook will be a valuable resource for the busy nursery provider.

Dr. Cantey is a board certified neonatalist specializing in infectious diseases and perinatal medicine. He received his medical degree from the Medical University of South Carolina in 2006 before completing his fellowships in pediatric infectious diseases and neonatal/perinatal medicine at the University of Texas, Southwestern Medical Center. He has published numerous journal articles and book chapters and is currently an assistant professor at Texas A&M Health Science Center College of Medicine.