Transfusion Management of the Obstetrical Patient. A Clinical Casebook

1. Obstetrical Management of Postpartum HemorrhageMichael Dombrowski, Michael Paidas
2. Laboratory Testing and Predictors of Severe Postpartum HemorrhageEvelyn Lockhart
3. Component Therapy in Obstetric HemorrhageJoseph Griggs
4. Evidence for 1:1:1 Transfusion Support and Importance of a Hemorrhage ProtocolMark Fung, Sara Harm
5. Evidence for/against Administration of Anti-fibrinolytic Agents during an Obstetrical HemorrhageKerry L. O'Brien
6. Evidence for/against Administration of Fibrinogen Concentrate and Coagulation Factor Concentrate during an Obstetrical HemorrhageMichael Dombrowski, Michael Paidas
7. Recommendations on Blood Recovery in Obstetrics Gerhardt Konig
8. Thrombocytopenia in PregnancyThomas G. DeLoughery
9. Von Willebrand Disease in PregnancyThomas G. DeLoughery
10. Platelet Count and Neuraxial AnesthesiaCathleen Peterson-Layne, Beth R. Burton
11. ABO CompatibilityTheresa Nester
12. RhD CompatibilityJessica Poisson
13. Other Rh Antibodies that Can Impact TransfusionJessica Poisson
14. Importance of Getting a Sample for ABO Type Early in a ResuscitationAshok Nambiar
15. Risks of Giving Uncrossmatched Red CellsAshok Nambiar
16. Management of Thrombotic Microangiopathies in PregnancyJeffrey L. Wintersa, Vesna D. Garovicb, Layan Alrahmanic, Kristina A. Davis
17. Hyperhemolysis Syndrome in a Pregnant Woman with Sickle Cell AnemiaHenry Hilt, Oyebimpe Adesina
18. Fetal and Neonatal Alloimmune ThrombocytopeniaJustin Juskewitch, Jeffrey Winters
19. Weak D in Pregnancy Meghan Delaney
20. Testing Algorithm for Rh Immune Globulin Dosing in the Post-natal RhD-negative MotherTheresa Nester
21. Pre-transfusion Testing in Women with High Bleeding Risk Requiring Prolonged HospitalizationTheresa Nester, Katherine L. Eastwood
22. Warm Autoantibodies During PregnancyChakri Gavva
23. Hemolytic Disease of the Fetus and Newborn/Selection of Red Cells for Intrauterine TransfusionBrian Gorospe, Nabiha Huq Saifee
24. Maternal Red Cell Alloantibody Directed Against a High Incidence Antigen Theresa Nester

This clinical casebook covers transfusion medicine theory and its practical implications for the obstetrical hemorrhage patient through the presentation of cases on actively bleeding patients. Each case features a unique clinical scenario involving a bleeding patient and outlines different aspects of safe and effective transfusion support. The cases contain current evidence on the latest topics in the field, such as the use of antifibrinolytic agents and coagulation factor concentrates in the setting of massive obstetrical hemorrhage. In addition to the actively bleeding patient, the casebook includes other important management topics, including the role of plasma exchange in thrombotic microangiopathies during pregnancy; treatment of hyperhemolysis in a patient with hemoglobinopathy; and recommended management of patients with red cell antibodies found on prenatal testing. Other immunohematology topics such as post-natal management of an RhD negative woman for the prevention of hemolytic disease of the newborn due to anti-Rh(D) are included.

Written by transfusion medicine, coagulation, obstetrical, and anesthesiology experts, Transfusion Management of the Obstetrical Patient: A Clinical Casebook is a concise yet comprehensive resource for anesthesiologists, obstetricians, pathologists, hematologists, and other practitioners who treat obstetrical hemorrhage patients.

Theresa Nester, MDMedical Director of Integrated Transfusion Service LaboratoriesProgram Director, Transfusion Medicine FellowshipBloodworks NorthwestUniversity of Washington Medical CenterDepartment of Laboratory MedicineSeattle, WA USA