Molecular Applications in Cytology

1. Why cytology for molecular testing? Pros and ConsLukas Bubendorf 2. How to prepare cytological samples for molecular testing Claudio Bellevicine, Umberto Malapelle, Elena Vigliar, Pasquale Pisapia, Carlo Ruosi, Giancarlo Troncone3. Molecular tests use in cytological material (analytical phase)Zsofia Balogh, Philippe Vielh 4. Molecular cytology applications on Head and NeckMarc P. Pusztaszeri, Joaquin J. Garcia, William C. Faquin 5. Molecular cytology applications on LungAlessia Di Lorito, Daniel Stieber, Fernando C. Schmitt6. Molecular Cytology of Serous EffusionsBen Davidson 7. Molecular cytology applications on UrineSpasenija Savic 8. Molecular cytology applications on Gynecological cytologyFrancesca Carozzi, Giovanni Negri, Cristina Sani 9. Molecular Applications in Hematolymphoid CytologyJoerg Schwock, Graeme Quest, William R. Geddie10. Molecular Cytology Application on ThyroidEsther Diana Rossi, Massimo Bongiovanni 11. Molecular cytology applications on Pancreas and Biliary TractRene Gerhard, Roseann I. Wu, Norge Vergara 12. Molecular cytology applications in Soft tissue (Pediatric tumors)Kossivi E. Dantey, Sara Monaco 13. Molecular cytology applications in metastasesFrancisco Beca, Fernando Schmitt 14. Clinical integration of molecular results on cytology (post-analytical phase)Perry Maxwell, Fernando Schmitt, Manuel Salto-Tellez

This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice.

Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology.

Professor Fernando Schmitt is currently Professor of Pathology and Medical Faculty of Porto University and Head of Molecular Pathology Unit at IPATIMUP, Porto. After finishing Medical School in Brazil in 1983, he was Assistant Professor of Anatomic Pathology at the Medical Faculty of Santa Maria and Associate Professor of Anatomic Pathology at the University of Sao Paulo. In 2004, he started working at the Medical Faculty at the University of Porto where he was Associate Professor of Pathology and Director of Molecular Pathology Unit at IPATIMUP. From 2013-2014, Professor Schmitt was full professor of pathology at the University of Toronto and from 2014-2016 was Director of the Department of Pathology at Laboratoire National de Sante, Luxembourg.

Professor Schmitt currently is the General Secretary of the International Academy of Cytology and President of the Portuguese Society of Cytology. He also been President of the European Federation of Cytology Societies and Chairman of the Working Group of Cytopathology of the European Society of Pathology. Professor Schmitt is a member of many journal editorial boards, including Acta Cytologica, Diagnostic Cytopathology, Cancer Cytopathology, Cytopathology, BMC Cancer and the Journal of Clinical Pathology. Professor Schmitt has published more than 400 scientific papers and is an experienced international lecturer. Together with Gary Tse and Puay Hoon Tan, he has published the book Fine Needle Aspiration Cytology of the Breast with Springer in 2013.