Neutrophilic Dermatoses

Introduction.- Historical milestones.- The skin conditions of the ND spectrum.- Sweet syndrome.- Pyoderma gangrenosum.- Subcorneal pustular dermatosis.- Pitfalls in the pathologic diagnosis of the ND.- The extra-cutaneous localizations of the ND : The Neutrophilic disease.- The ND in systemic diseases.- Pathophysiology of the ND.- Therapy.- Conclusion and future prospects.

This book provides an in depth overview of Neutrophilic Dermatoses, a group of diseases that includes Sweet's syndrome, pyoderma gangrenosum and subcorneal pustular dermatosis. Although there are still some gaps in the knowledge, it is now clear that their pathophysiology implies that mechanisms associated with auto-inflammation are involved, while many of these dermatoses occur in the setting of other systemic inflammatory diseases (colitis, arthritis) and of malignancies (blood malignancies, solid cancers). As such it is an important area of study within internal medicine. Neutrophilic Dermatoses represents an extensive clinical review of the group of diseases and is a critical resource for all medical professionals managing these patients, including clinicians in dermatology, gastroenterology, hematology, oncology, pediatrics and primary care.

Dr. Wallach is a graduate of University of Paris Faculty of Medicine. He was Senior Lecturer in the Departments of Dermatology of Hopital Saint-Louis and Hopital Tarnier in Paris, France. In addition to membership in the French Society of Dermatology, the American Academy of Dermatology, and the Society for Investigative Dermatology, Dr. Wallach founded and chaired the French and the European societies for the history of dermatology. His interests include medical dermatology, neonatal dermatology, and the history of dermatology.

Dr. Vignon-Pennamen is a dermatopathologist working in the Hopital Saint-Louis in Paris and a specialist in managing complex inflammatory skin conditions. Dr. Marzano is Professor of Dermatology at the University of Milan and works in the Dermatology Unit of the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan, Italy.

Professor Marzano is a world-known leader in dermatology and in immuno-dermatology, and he is currently the Chairman of the very active Italian Group of Immunodermatology. He described clinical entities inside the neutrophilic dermatoses'spectrum, such as the aseptic pustulosis of the folds and the PAPASH syndrome, and published many studies on the pathophysiology of neutrophilic dermatoses.