PART I INTRODUCTION: Anatomy and Physiology of the Thyroid Gland.- The Hypothalamic-Pituitary-Thyroid Axis: Physiological Regulation and Clinical Implications.- Thyroglobulin storage and degradation for thyroid hormone liberation.- Disorders of thyroid hormone transporters and receptors.- Deiodination and peripheral metabolism of thyroid hormone.- PART II BASIS OF THYROID DISEASE: Epidemiology of thyroid diseases.- Classification of thyroid diseases.- Iodine Deficiency.- Selenium Deficiency and Thyroid Disease.- PART III DIAGNOSTIC & THERAPEUTIC APPROACHES: Laboratory testing in thyroid disorders.- Ultrasonography of the Thyroid and Cervical Lymph nodes.- The role of elastography in the management of thyroid nodules.- DTC imaging with Iodine-124 and F-18-FDG.- Surgery for benign goiter.- PART IV HYPOTHYROIDISM: The thyroid and its regulation by the TSHR: Evolution, development and congenital defects.- Hypothyroidism.- Central hypothyroidism.- Subclinical hypothyroidism.- Treatment of hypothyroidism.- Myxedema coma.- Heart in Hypothyroidism.- PART V HYPERTHYROIDISM: Graves' disease.- Graves' Ophthalmopathy.- Subclinical hyperthyroidism.- Thyroid storm.- Heart in Hyperthyroidism.- PART VI THYROIDITIS: Chronic autoimmune thyroiditis.- Acute infectious thyroiditis (Acute suppurative thyroiditis).- Postpartum thyroiditis.- Amiodarone-induced thyroid dysfunction.- Iodine-induced thyroid dysfunction.- PART VII THYROID NEOPLASIA: Pathology of the thyroid: A review.- Thyroid nodules: Current Evaluation & Management.- Non-toxic Multinodular goiter.- PART VIII THYROID CANCER: Epidemiology of Thyroid Cancer.- Molecular Genetics and Diagnostics of Thyroid Cancer.- Thyroid Cancer in Children and Adolescents.- Thyroid Cancer Surgery.- Staging and Prognosis of Thyroid Cancer.- Radioiodine Therapy in Differentiated Thyroid Carcinoma.- Dosimetry for 131I Therapy for Metastatic Differentiated Thyroid Cancer.- Thyroid Cancer: Targeted Molecular Therapy.- Thyroid Cancer: Thyroglobulin & TgABs.- Medullary thyroid cancer.- Anaplastic Thyroid Carcinoma.- Primary Thyroid Lymphoma.- The Role of TSH Suppression in the Management of Differentiated Thyroid Cancer.- PART IX MISCELANEOUS TOPICS: Hyperthyroidism and Pregnancy.- Thyroid hormone resistance syndromes.
This book is an up-to-date and comprehensive guide to all the common thyroid disorders that may be seen by internists, endocrinologists, nuclear medicine physicians, and endocrine surgeons. While the fundamentals of thyroid hormone function and regulation in health and disease are well covered, the primary focus is on the clinical approach to thyroid disease, with detailed coverage of both initial diagnosis and management and the role of imaging. Because most endocrine diseases are chronic and lifelong, special emphasis is placed on long-term management and the common pitfalls that may be encountered by the clinician. The editors are internationally acknowledged leaders in the field of thyroid disease and have gathered an outstanding team of authors, all of whom are also highly expert in their respective areas, but who, equally importantly, write in a clear and lucid style. The numerous isotope scan and ultrasonographic images ensure that the book will serve as a valuable reference atlas to which the physician will return again and again.
Markus Luster, MD, University Hospital Marburg, Department of Nuclear Medicine, Marburg, Germany
Leonidas H. Duntas, MD, University of Athens Evgenidion Hospital, Department of Endocrinology, Athens, Greece
Leonard Wartofsky, MD, Georgetown University Washington Hospital Center, Department of Medicine, Washington DC, USA