Cardio-Renal Clinical Challenges

Description

In modern medicine, the aging population is prone to many simultaneous cardiovascular (CV) riskfactorswhich often produce co-incident pathology. Nowhere is this more obvious than in the interaction between Chronic Kidney Disease (CKD), Diabetes and diverse CV diseases (CVD). This is a complex and challenging area, as the presence of CKD/diabetes promotes CVD while also complicating its treatment. The emergence of CKD as a public health priority is one of the most challenging problems of modern medicine. It is now solidly established that renal dysfunction portends a high risk for cardiovascular disease. Cardiovascular diseases remains the main cause of death in western societies and the amplification of the death risk conveyed by coexisting CKD, even though still poorly understood, appears considerable. The bidirectional link that associates renal and cardiovascular diseases, the high risk of the death signalled by their coexistence and the considerable epidemiological burden imposed by this link is at the basis of the emergence of a new discipline aiming at making the borders between nephrology and cardiovascular medicine even more permeable than before. The term Cardio-Renal Syndrome was coined around 5 years ago to try to formalize this link, and act as a stimulus to interaction between clinical teams, researchers and others to achieve better management and outcomes for all.

This booktakes clinical presentations and clinical problems as its base, and then discuss the evidence for best management of common clinical problemsas well as the reasons for the complex interplay between the cardiac and renal systems. Moreover, it addresses the issue of organizing healthcare to maximize the opportunities for prevention and best healthcare economic returns, building on cutting edge initiatives at the Karolinska,Stockholm.

The book will be of immediate value and interest to all cardiologists and renal physicians.

Table of Contents

Epicardial coronary heart disease in chronic kidney disease: diagnosis and management.- Small vessel disease in CKD, Diabetes, obesity and Hypertension.- Sudden Cardiac Death and Arrhythmia in Chronic Kidney Disease.- Anticoagulation in Chronic Kidney Disease.- MRA inhibition in CKD: more than salt and water.- Vascular effects of inflammation and oxidative stress in CKD.- Uric acid, allopurinol: the cardio-renal silver bullet?.- FGF23 and phosphate: two cardiovascular toxins with distinct toxicity profiles?.- Renal congestion in heart failure.- Effect of Vitamin D on Endothelial Function and Blood Pressure.- Vitamin D and its effects on the heart.- Volume overload in chronic kidney disease: Pathophysiology, Assessment techniques, Consequences and Treatment.- Reversing Arterial Stiffening And Calcification - A Pipe Dream?.- Pulmonary Hypertension in Chronic Kidney Disease: a new problem child.- How To Use Inhibitors Of The Renin-Angiotensin-Aldosterone System In Patients With Chronic Kidney Disease And Heart Failure.- Erectile and sex hormone dysfunction and cardiovascular consequences in chronic kidney disease.- Renal Sympathetic Denervation in the Management of Treatment-Resistant Hypertension.- Future Therapeutic Prospects for Treatment of Cardiorenal Syndromes.- Novel combination therapy to target heart and kidney.- Challenging complex diseases.- Is “Me, Me, Me” the new “We, We, We”? : Can we afford (not) to take the plunge into the personalised, stratified medicine era?.- Psychological distress in physical long-term conditions.