Chronic Myeloid Neoplasias and Clonal Overlap Syndromes: Epidemiology, Pathophysiology and Treatment Options

About this atlas

• Comprehensive review on pathophysiology and therapy on Chronic Myeloid Diseases
• Easy to follow diagnostic algorithms on the clinical management
• Well illustrated with clinical photos, clear graphics and illustrations

This book comprises an in depth view on the current knowledge of chronic clonal myeloid diseases. Special emphasis is laid on chronic myeloid leukaemia and ‚classic’ myeloproliferative disorders (essential thrombocythemia, polycythemia vera, chronic idiopathic myelofibrosis) as well as myelodysplastic syndromes, oligoblastic leukemias, paroxysmal nocturnal hemoglobinuria and overlap diseases. Both young physicians in hematological training as well as practicing hematologists are addressed, with the aim of imparting a clear understanding of these disorders. In-depth information on the most relevant cell-biological pathways is accentuated by graphics. Guidelines for diagnosis, complemented by cytological, histological and clinical photos, as well as easy-to-follow algorithms with clinical as well as laboratory findings are provided. Current management of routine as well as precarious clinical situations are discussed and supplemented with boxes highlighting the most relevant information in keywords.

Written for: Oncologists, internists, medical doctors

Keywords:

• Leukemia
• Myelodysplastic Syndroms
• Myeloproliferative Disorders
• Myeolid Disorders
• Therapy

Table of contents

1. Chronic Myeloproliferative Disorders (CMPDs)

1.1. Essential Thrombocythemia (ET)
1.1.1. Autosomal Dominant Familial Essential Thrombocythemia
1.1.2. Philadelphia Chromosome Positive ET and Bcr/Abl Positive ET
1.2. Polycythemia Vera (PV)
1.2.1. Autosomal dominant Familial PV
1.3. Melofibrosis with Myeloid Metaplasia (MMM)
1.3.1. Agnogenic Myeloid Metaplasia (AMM) or Chronic Idiopathic Myelofibrosis (CIMF 32)
1.3.2. Atypical Variants
1.3.3. Secondary MF

2. Myelodysplastic Syndroms

2.1. MDS-variants
2.1.1. Therapy-related MDS
2.1.2. Hypocellular MDS
2.1.3. Hyperfibrotic MDS
2.1.4. 5p-Syndrome
2.1.5. 17p-Syndrome
2.1.6. Monosomy 7 Syndrome
2.1.7. Trisomy 8
2.1.8. 3q21q26 Syndrome
2.1.9. Overlap Syndromes
2.1.9.1. Paroxysmal nocturnal haemoglobinuria (PNH) and MDS/PNH
2.1.9.2. Aplastic anemia (AA) and AA/PNH
2.1.9.3. Large granulocytic lymphoma (LGL) and MDS/LGL

3. Atypical Chronic Myeloid Disorders

3.1. CMML
3.2. Atypical CML
3.3. Chronic Neutrophilic Leukemia
3.4. Mast Cell Leukemia
3.5. Chronic Eosinophilic Leukemia
3.6. Chronic Myelogenous Leukemia
3.6.1. Atypical CML