Infection, Immune Homeostasis and Immune Privilege (Birkhäuser Advances in Infectious Diseases)

Description

• Connects the knowledge of immune regulation in different tissues
• Adds insight to readers’ understanding of the “Hygiene hypothesis”
• Presents basic science aspects relevant for diagnosis and disease management
• Adds insight to readers’ understanding of the “Hygiene hypothesis”
• Presents basic science aspects relevant for diagnosis and disease management
• Presents basic science aspects relevant for diagnosis and disease management

Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms.

This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.

Content Level » Research
Keywords » immune homeostasis - immune privilege - inflammation
Related subjects » Medical Microbiology - Molecular Medicine

TABLE OF CONTENTS

• Introduction.
• The Eye as Immune Privileged Site.
• Immune Privilege of the Testis – Meaning, Mechanisms and Manifestations.
• The Role of Intrauterine Immune Privilege in Perinatal Infectious Diseases.
• The Liver as an Immune Privileged Site.
• Immune Homeostasis of the Lung: The Role of Regulatory NKT Cells in Asthma.
• Immune Homeostasis of the Gut.