Clinical Management of Challenges In Allogeneic Stem Cell Transplant

1. Front Matter

   Pages i-viii

2. Access to Transplant Care and Social Determinants of Health

   • Krithika Shanmugasundaram, Karen Ballen

   Pages 1-8

3. Allogeneic Transplantation for Older Adults

   • Ashley D. Hadjis, Shannon R. McCurdy

   Pages 9-40

4. Conditioning Regimen Options

   • Zheng-Li Xu, Xiao-Jun Huang

   Pages 41-55

5. Graft Source Choice

   • Sanghee Hong, Mitchell E. Horwitz

   Pages 57-75

6. Optimal GVHD Prophylaxis

   • Hany Elmariah, Javier Bolaños-Meade

   Pages 77-102

7. Modern-Era Challenges in the Clinical Management of Graft-Versus-Host Disease

   • Catherine J. Lee, Paul A. Carpenter

   Pages 103-128

8. Acute Myeloid Leukemia-Use of Measurable Residual Disease to Improve Outcomes

   • Jesse M. Tettero, Christopher S. Hourigan

   Pages 129-148

9. Acute Lymphoid Leukemia: Is Transplant Indicated for Philadelphia Chromosome Positive ALL?

   • Ryszard Swoboda, Arnon Nagler

   Pages 149-166

10. Myelofibrosis: Timing of Transplantation and Management of Splenomegaly

    • Nicolaus Kröger, Kristin Rathje, Nico Gagelmann

    Pages 167-175

11. Hematopoietic Stem Cell Transplantation in Sickle Cell Disease

    • Mohammed Essa, Mohsen Alzahrani, Ali D. Alahmari, Mahmoud Aljurf

    Pages 177-191

12. Pharmacological Maintenance Therapies After Allogeneic Hematopoietic Cell Transplantation

    • Ritika Walia, Yi-Bin Chen

    Pages 193-207

13. Challenges and Opportunities in the Care of Hematopoietic Cell Transplant Survivors in the Modern Era

    • Neel S. Bhatt, Alexis Richards, Kristen L. Beebe, Nandita Khera

    Pages 209-226

14. Back Matter

    Pages 227-228

The purpose of the book is to focus attention and offer suggestions on controversial and challenging topics in allogeneic stem cell transplant. Over 40,000 allogeneic hematopoietic cell transplants (HCT) are done worldwide each year. Despite advances in allogeneic transplant, the cure rate is only 50-70%, depending on disease and patient factors. The book focuses on key topics such as patient selection, donor selection, conditioning regimens, graft vs. host disease prophylaxis regimens, maintenance strategies, and other topics that affect patient outcomes. The authors also discuss access to transplant care. Through dissemination of these topics, we hope to educate health care professionals caring for these patients, and improve patient outcomes. This is an essential resource for transplant physicians, hematologists/oncologists, and advance practice providers. Several of the topics are controversial issues that are discussed “round the table” frequently by transplant teams.