Frailty. A Multidisciplinary Approach to Assessment, Management, and Prevention

Cover
Front Matter
Part I. Frailty and Related Concepts: An Overview
1. The Frailty Phenotype
2. Deficit Accumulation
3. Prevalence, Incidence, and Risk Factors of Frailty
4. Integration: A Unified Frailty Framework
5. Intrinsic Capacity
6. Transitions, Trajectories, and Reversibility
7. Sarcopenia and Frailty: A Common Thread Across Multiple Comorbidities
8. Complications of Frailty
9. Sex Differences and Frailty
Part II. Mechanisms: Pathogenesis and Research
10. Inflammaging and Immunosenescence
11. Implications of the Exposome for Frailty
12. Preclinical Models of Frailty
13. Biomarkers of Frailty
14. Mitochondrial Alterations and Signaling in Aging, Frailty, and Sarcopenia: An Integrated View
15. Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms
Part III. Assessment
16. Clinical Frailty Scale
17. Frailty Measure Development, Selection, and Implications
18. Pictorial Fit-Frail Scale
19. Frailty Assessment: The FRAIL Scale
20. Edmonton Frail Scale
21. The Tilburg Frailty Indicator (TFI)
22. The Study of Osteoporotic Fractures (SOF) Frailty Index
23. Physical Assessments Instruments
24. Technology-Based Assessments of Frailty
25. Frailty Tools Using Health Care Databases
Part IV. Management: Treatment and Prevention
26. Comprehensive Geriatric Assessment CGA
27. Exercise Strategies for Improving Health Outcomes in Older Adults with Comorbidities: The Role of Vivifrail Tailored-Multicomponent Training
28. Nutritional Aspects of Frailty in Older Adults: Undernutrition, Nutrients Consumption, and Diet Patterns
29. Deprescribing
30. Geroscience-Based Interventions
31. Integrated Care for Frailty
Part V. Settings of Care
32. Frailty in Primary Care: Interventions and Opportunities
33. Frailty in Acute Care Settings
34. Frailty in Nursing Homes
35. Rehabilitation
36. Palliative Care
37. Frailty in Home Care
38. A Community-Based Model for Detecting and Managing Frailty
Part VI. Other Conditions
39. Bidirectional Relationships Between COVID-19 and Frailty in Older Adults
40. Frailty and Cancer
41. Frailty and Cardiovascular Disease
42. Frailty in Older People with Diabetes Mellitus
43. Frailty and Cognition. Fellow Travelers or Partners in Crime?
44. Frailty and Orthogeriatrics: Enhancing Care for Fragility Fractures
45. Frailty in Older Adults with Obesity and the Effect of Lifestyle Interventions
46. Vaccines, Vaccine-Preventable Diseases, and Frailty
47. Oral Health and Frailty
48. Perioperative, Surgical, and Procedural Care for Older Adults with Frailty
49. Delirium
Part VII. Social and Other Issues
50. Social Determinants of Physical Frailty
51. Educating and Training the Workforce
52. Frailty in Low- and Middle-Income Countries
53. Ethical and Policy Aspects of Frailty
Back Matter

This book offers a thorough examination of frailty, covering its complexity through sections on foundational concepts, pathogenesis research, assessment methods, management strategies, care settings, its relation to other chronic conditions, and societal implications. It provides a deep understanding of frailty's scientific basis, advanced assessment tools, innovative management, and prevention approaches, and examines frailty within diverse care settings and in relation to other health conditions. By integrating multidisciplinary insights, it presents a holistic view of frailty, addressing its clinical, societal, and policy-related aspects, aiming to enhance well-being and inform clinical practitioners, educators, and policymakers. This book can serve as a reference guide with up-to-date information on frailty in older adults for geriatric medicine physicians, primary care clinicians, geroscience researchers, nurses, therapists (OT, PT, ST), and social workers.

Jorge G. Ruiz, MD, FACP, Medical Director, Geriatric Medicine, Memorial Healthcare System, Hollywood, Florida, and Clinical Affiliate Professor of Geriatric Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, Florida, USA.

Olga Theou, PhD, Canada Research Chair in Physical Activity, Mobility, and Healthy Aging and Associate Professor of Physiotherapy and Geriatric Medicine at Dalhousie University, Halifax, Nova Scotia, Canada