Early Detection and Treatment of Head and Neck Cancers. Practical Applications and Techniques for Detection, Diagnosis, and Treatment

Early Detection, Diagnosis, and Treatment of Head and Neck Cancers.- Emerging Technologies in Head & Neck Cancer Detection: Industry landscape of Head and Neck Cancer Detection and Diagnosis.- Microfluidic Technologies for Head and Neck Cancer: from Single Cell Analysis to Tumor-on-a-chip.- Nanotechnology for Diagnosis Imaging and Treatment of Head & Neck Cancers.- The Role of Mass Cytometry in Early Detection, Diagnosis, and Treatment of Head and Neck Cancers.- Deep Learning based Cancer Detection from H&E Slide of HPV-associated Oropharyngeal Tumors.- Salivary Biomarkers for Non-invasive Early Detection of Head and Neck Cancer.- Surgical Ablative Treatment of Head and Neck Cancer.- Conventional Reconstructive Approaches following Resection of Head and Neck Cancers.- Dental Implants and their Management in the Treatment of Oral Cancers.

Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. Volume I begins with a general overview, including the industry landscape, of HNC detection, diagnosis, and treatment. Next, it covers the applications of innovative technologies such as microfluidics, nanotechnology, and deep learning to early detect as well as study HNC. For example, studying the cellular features at a single-cell level became possible with the advancement of technologies such as mass cytometry or specifically, Cytometry by Time Of Flight Mass Spectrometry (CyTOF), which has revolutionized the way we can study complex human diseases such as HNC. Finally, the last few chapters are dedicated to describing the standard of care of HNC.

The first volume of Early Detection and Treatment of Head & Neck Cancers is highly pertinent to the next generation of interdisciplinary clinicians, scientists, residents, and students who are particularly interested in HNC and in the translation of early detection methods, technologies, and research to clinical practice.

Author Information

Rami El Assal, DDS, FADI, is a Former Research Scientist (Academic Staff) at the Canary Center for Cancer Early Detection, Stanford University School of Medicine, Stanford, California. He completed a Postdoctoral Research Fellowship at Stanford University School of Medicine. Prior to Stanford, Dr. El Assal completed a Postdoctoral Research Fellow at the Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts as well as the Harvard-MIT Health Science and Technology Division. He received his DDS degree from Ajman University, School of Dentistry, Ajman, UAE. Dr. El Assal research achievements have been recognized by numerous entities such as the Center of Nanoscale Systems at Harvard University, Academy of Dentistry International, and International Academy of Dental-Facial Esthetics. He published over 40 peer-reviewed articles, conference proceedings, and abstracts, as well as 2 edited books.

Dyani Gaudilliere, DMD, MPH, is the Chief of the Section of Dental Medicine & Surgery and a Clinical Assistant Professor in the Division of Plastic and Reconstructive Surgery, Department of Surgery at Stanford University School of Medicine, Stanford, California. She also serves as an Adjunct Assistant Professor of Diagnostic Sciences at the University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, California. Dr. Gaudilliere received her DMD from Harvard School of Dental Medicine, Boston, Massachusetts, and her MPH from University of California at Berkeley. In addition, she completed a General Practice Residency Program at the University of California at San Francisco (UCSF) School of Dentistry. She is the leader of Stanford's Dental Oncology clinical program, has many clinical teaching responsibilities, and has authored over 20 journal articles in the fields of immunology, oral surgical education, and implantology.

Stephen T. Connelly, DDS, MD, PhD, FACS, is an Attending Oral and Maxillofacial Surgeon at the San Francisco Veteran Affairs Medical Center and an Associate Professor in the Department of Oral and Maxillofacial Surgery at University of California at San Francisco (UCSF)-School of Dentistry. He carries out a mixture of clinical and operating room procedures, including oral and head and neck cancer surgery, dentoalveolar surgery, bone grafting and implant procedures, and extensive temporomandibular joint surgery. In addition, he maintains a part-time private practice at Bay Area Oral and Facial Surgery in San Francisco. Dr. Connelly received his DDS Columbia University College of Dental Medicine, New York, and completed his Oral Maxillofacial Residency with an MD degree at the UCSF-School of Dentistry and School of Medicine. In addition, he also completed a PhD in Cranio-maxillofacial Sciences at the UCSF- School of Dentistry. He has received a number of honors and awards and is the author of 25 peer-reviewed publications and the editor of 3 books.