1. Introduction and history.- 2. Basic principles of drug delivery and dosing.- 3. Sulfonamides.- 4. Penicillins.- 5. Cephalosporins.- 6. Monobactams: Aztreonam.- 7. Carbapenems.- 8. Glycopeptides and other agents used to treat gram-positive cocci.- 9. Vancomycin: New Area-under-the-curve-based therapeutic monitoring.- 10. Aminoglycosides.- 11. Macrolides.- 12. Metronidazole and clindamycin.- 13. Quinolones.- 14. Tetracyclines.- 15. Pleuromutilin.- 16. Antimicrobial stewardship: evolution into the 21st century.- 17. Clinical approach to the treatment of infectious diseases.- 18. Understanding drug allergies and drug toxicities.- 19. Antibiotic-associated diarrhea.- 20. Principles of antibiotic resistance.- 21. Clinical approach to treatment of bacterial infections.- 22. Clinical approach to treatment of mycobacterial infections.- 23. Clinical approach to treatment of fungal infections.- 24. Clinical approach to treatment of viral infections.- 25. Sample cases and analyses of the use of anti-infective agents: Cases 1-15.- Appx A. Common infectious diseases and empiric antibiotic recommendations for adult ed and inpatients at UMass Memorial Medical Center.- Appx B. Bioavailability of anti-infective agents.- Appx C. Dosage and intervals for administration of IV antimicrobials.- Appx D. Dosage and intervals for administration of oral antimicrobials.- Appx E. Important interactions with commonly-used anti-infectives.- Appx F. Oral agents that may have interactions with food.- Appx G. Drug interactions with anti-retroviral agents.- Appx H. Dosage in obesity.- Appx I. Recommendations for management of Asymptomatic Bacteriuria (ASB): 2019 update.- Appx J. Guidelines for treatment of C. difficile.- Appx K. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression.- Appx L. Guidelines for treatment of adults with community-acquired pneumonia.- Appx M. Guidelines for management of adults with hospital-acquired and ventilator-associated pneumonia.- Appx N. Guidelines for antimicrobial prophylaxis for surgery.- Appx O. Guidelines for treatment and chemoprophylaxis of influenza.- Appx P. Antimicrobial dosing in adult patients on extracorporeal membrane oxygenation (EXMO).- Appx Q. Antimicrobial dosing in neonates.-
This second edition of Clinical Use of Anti-Infective Agents provides a comprehensive overview of current approaches to using drugs to treat infections, including historical perspectives, definitions, and discussion of pharmacokinetics and pharmacodynamics and their uses. It includes a detailed explanation of different classes of drugs, outlining their spectrum, pharmacokinetics, side effects, and dosing in clinical settings. This book has been designed as a reference tool for pharmacists, clinicians, nurse practitioners, and clinical microbiologists, as well as a teaching vehicle for students studying infection and patient treatment.
Each section includes references allowing for in-depth study of specific agents, Q&As, and illustrative case studies accompanied by commentary on how to approach patients and organisms, optimal methods of making a diagnosis, and prescribing treatment.
Robert W. FinbergRichard Haidack Professor and ChairDepartment of MedicineUniversity of MassachusettsMedical SchoolWorcester, MA, USA
Roy GuharoySystem Vice PresidentBaptist Health System, Montgomery, ALUMass Memorial Health Care Clinical Professor of Medicine University of Massachusetts Medical School Worcester, MA, USA Roy.Guharoy@umassmemorial.org