Neuroimmunology. Multiple Sclerosis, Autoimmune Neurology and Related Diseases

Part 1 Immunology, Pathophysiology and Immunotherapy Introduction to Immunology and Overview of the Immune System (BBB, Lymphatics, innate and adaptive immune system)Immunology of Multiple sclerosis (Role of B, T and innate immune system) Pathology of Multiple sclerosis Antibody pathogenesis and detection method for neuronal autoantibodies (Testing methods IFA, CBA, ELISA etc., (Synaptic vs intracellular antibodies in autoimmune/paraneoplastic disease) Mechanisms and Principles of Immunotherapy

Part 2 Multiple Sclerosis Natural history of MS (relapses/progressive MS) Evolution of the diagnostic criteria in MS (MRI, CSF, OCT/VER) Epidemiology/Demographics/Environmental effects of MSPediatric MSTreatment of MS Trial design (ARR/MRI metrics/biomarkers) Disease modifying treatments Treatment selection and Treatment discontinuation

Part 3 Autoimmune Neurology Autoimmune Encephalitis Autoimmune Myelitis and Myelopathy Autoimmune Epilepsy Autoimmune Movement Disorders Autoimmune Demyelinating disease: NMOSD and anti-MOG Autoimmune Ophthalmologic disease Autoimmune Neurology in Pediatrics (might need to include discussion on ADEM in this chapter) Treatment Approaches in Autoimmune Neurology (Overall lack of clinical trials and barriers, Current treatment approach)

Part 4 Other CNS inflammatory diseases Neurorheumatology Neurosarcoidosis Vasculitis Hypertrophic Pachymeningitis (To include a discussion on IgG-RD)Role of infection and immunodeficiency in inflammatory disease Role of Oncological disease in inflammatory disease (to include lymphoma, CLIPPERS, Erdheim Chester)

This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches.

Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader's knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book.

Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

Amanda L. Piquet, MD
University of Colorado
School of Medicine
Aurora, CO, USA

Enrique Alvarez MD, PhD
University of Colorado
School of Medicine
Aurora, CO, USA