Meningiomas. Comprehensive Strategies for Management

Meningiomas: Overview.- Histopathology and Grading of Meningiomas.- Radiology.- The Genomic Landscape of Meningiomas.- The Initial Evaluation and Surveillance of Meningiomas.- Surgical Considerations for Newly Diagnosed Meningiomas.- Endoscopic and Minimally Invasive Meningioma Surgery.- Spinal Meningioma: Comprehensive Strategies for Management.- Radiation Therapy for the Management of Benign Meningioma.- Benign Tumor Recurrence and Management of More Aggressive Meningiomas.- Surgical Considerations for Recurrent Meningiomas.- Radiotherapy for Aggressive Meningiomas and Recurrent WHO Grade I Meningiomas.- The Role of Medical Therapy.- Emerging Therapies I: Precision Medicine, Targeted Therapies, and Mutation-Specific Approaches.- Emerging Therapies II: Immunotherapies, Novel Radiotherapy Techniques and Other Experimental Approaches.

This book provides a comprehensive overview of the multidisciplinary management of meningiomas, followed by evaluation and management considerations along a spectrum of benign to more malignant behavior. It outlines the management of presumed Grade 1 tumors and how to identify features of tumors radiographically and clinically that may support a benign course rather than aggressive and vice versa. Following a stepwise progression from simple to complex, chapters introduce and tackle more aggressive meningiomas and tumor recurrence (of all Grades), with paradigms for evaluation and treatment. Tumor biology and genomics are fundamental and largely focused in the book. More recent findings which have directed personalized medicine and clinical trials are also addressed.

Meningiomas: Comprehensive Strategies for Management addresses all aspects of the evaluation and care of patients with all WHO grades of meningiomas. It is highly informative and provides clarity for a wide audience of neurosurgeons, reconstructive surgeons, oncologists, neurologists, radiation oncologists, pathologists, radiologists, residents and students who treat these patients and those who are training for a career in managing patients with these potentially challenging tumors.

Jennifer MoliternoChief of Neurosurgical Oncology, Yale New Haven Hospital and Smilow Cancer HospitalCo-Director, Yale Brain Tumor Center at Smilow Cancer HospitalAssociate Professor, Department of Neurosurgery, Yale School of Medicine, Yale UniversityDepartment of Neurosurgical OncologyYale School of MedicineNew Haven, CT USA

Antonio OmuroChief of Neuro-Oncology, Yale New Haven Hospital and Smilow Cancer HospitalDirector, Yale Brain Tumor Center at Smilow Cancer HospitalProfessor, Department of Neurology Yale School of Medicine, Yale UniversityNew Haven, CT USA