Klinefelter’s Syndrome. From a Disabling Condition to a Variant of Normalcy

Preface
1. Introduction - From a disabling condition to a variant of normalcy
2. Epidemiology of an underdiagnosed syndrome
3. Causes of the extra chromosome/s
4. Different karyotypes, same disease?
5. Genetic and epigenetic aspects of the supernumerary X chromosome
6. Prenatal Counselling and management in the early neonatal period
7. EARLY DEVELOPMENTAL PATHWAYS AND COMMUNICATION GOOD PRACTICES
8. THE DIAGNOSIS AT PREPUBERTAL AGE
9. WHAT TO DO AND WHEN FROM INFANCY TO PUBERTY
10. Neuropsychiatric aspects
11. Testicular development
12. THE KLINEFELTER PUBERTY
13. GENETIC OF GAMETES
14. Phenotype of the adulthood
15. Hypothalamic-Pituitary Axis Function
16. the altered bone
17. Obesity, the rule or not
18. Lipids and glucose metabolism
19. Cardiovascular characteristics
20. The Thyroid Function
21. ONCOLOGICAL PROBLEMS
22. FERTILITY PRESERVATION
23. Fertility vs Infertility
24. Psychological features
25. Sexual function
26. Testosterone treatment in male patients with Klinefelter's syndrome

This book presents the latest insights into all the critical aspects of Klinefelter's Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more "evidence-based" support, and improving patient satisfaction.

It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.

Andrea Garolla is an Associate Professor of Endocrinology at the University of Padova's Department of Medicin, and he works as an endocrinologist and andrologist at the Unit of Andrology and Reproductive Medicine at the University Hospital of Padova. He received his MD degree at the University of Padova. From 2009 he taught in the International Master's on Male Reproduction at the University of Padova. From 2003 to 2015 he was a Consultant in Andrology at the Reproductive Center of Alto Adige, Hospital of Brunico, Bozen, Italy. From 2011 to 2015 he was a Consultant in Andrological Oncology at the Venetian Institute of Oncology (IOV) of Padova, and from 2015 to 2019 he was an Assistant at the Unit of Andrology and Reproductive Medicine, Department of Medicine at the University Hospital of Padova. Previously he was a member of the Directive Board of the Italian Society of Medical Andrology and Sexual Medicine (SIAMS) and a member of the Directive Board of the Italian Society of Reproductive Physiopathology (SIFR), and he is currently a member of the Scientific Board of the Italian Society of Endocrinology (SIE). He is co-author of more than 150 peer-reviewed scientific papers, 21 books, and numerous book chapters and invited reviews, and is co-editor of 10 books and author of three books. He is a member of the editorial board of Frontiers in Endocrinology and of the Journal of Pelviperineology, Genitourinary Oncology, Frontiers in Pharmacology, Journal of Clinical Cancer Research, Cancer Endocrinology. He is referee for several international and national scientific journals in the field of endocrinology, andrology, reproductive medicine, oncology and fertility preservation, and is regularly an invited speaker at national and international congresses.

Giovanni Corona works as endocrinologist and andrologist at the Endocrinology Unit of Maggiore-Bologna Hospital, Bologna, Italy. He received the MD degree from the University of Bologna, passed the board examination in Endocrinology and holds a Doctor of Philosophy degree from the University of Florence. He is co-author of more than 250 peer-reviewed manuscripts, and various book chapters and invited reviews in the field of endocrinology and sexual medicine. Since 2014 he has been a member of the board of the Journal of Endocrinological Investigation. He is also member of the editorial board of Andrology, Hormones, and the Journal of Sexual Medicine. From 2010 to 2015 he was an associate editor of the Journal of Sexual Medicine, and he is now the associate editor of the same journal. He is a member of the European Society of Endocrinology, and Academician of the European Academy of Andrology (EAA) and the co-chair of the "Guidelines Committee" of the EAA. In 2018 he became President of the Italian Society of Andrology and Sexual Medicine and was also nominated as the Chair of the Scientific Committee of the European Society for Sexual Medicine.