PART I PERIODONTAL THERAPIES TARGETING HOST IMMUNE AND INFLAMMATORY SYSTEM Chapter 1 Evolving Paradigms in the Pathogenesis and Management of Periodontitis.- Chapter 2 Complement C3 as a Target of Host Modulation in Periodontitis.- Chapter 3 Resolvins in Periodontal Tissue Homeostasis (Emerging Therapies).- Chapter 4 Salicylic Acid Polymers in Periodontal Tissue Healing.- Chapter 5 Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease.- Chapter 6 The IL17/Th17 Axis as a Therapeutic Target in Periodontitis.- Chapter 7 Epigenetic and Gene Modification Precision Medicine Approaches for the 'Chronic Destructive Perio-Diseases': Periodontitis and Periimplantitis.- Chapter 8 Cellular Senescence in Aging Mucosal Tissues is Accentuated by Periodontitis.- Chapter 9 Peri-implant Disease.- PART II PERIODONTAL THERAPIES TARGETING ORAL MICROBIOME Chapter 10 The Function of the Oral Microbiome in Health and Disease.- Chapter 11 Bacterial Peptides Targeting Periodontal Pathogens in Communities.- Chapter 12 Periodontal Pathogen Sialometabolic Activity in Periodontitis.- Chapter 13 Ecological Approaches to Periodontal Therapy.- PART III TISSUE ENGINEERING FOR PERIODONTAL REGENERATION Chapter 14 Protein and Cell Based Therapies for Periodontal Regeneration.- Chapter 15 Lasers in Periodontal and Peri-implant Therapy: Challenges and Opportunities.- Chapter 16 Spatiotemporal Controls of Tooth-Supporting Structure Neogenesis by 3D Printing Technology
This book equips dental care providers with a thorough understanding of the emerging therapies that promise to revolutionize the clinical management of periodontal diseases. Existing therapies targeted to the oral microbiome alone often fail to provide favorable clinical outcomes. Local inflammation and tissue destruction may persist and periodontal tissue regeneration is not predictably achieved. In recognition of these shortcomings, current research efforts are focused on understanding the biological interactions between the host and the resident microbiome and identifying key molecules and molecular pathways that can be used for more targeted, individualized therapies that will restrain oral inflammation and restore periodontal tissue homeostasis. This book introduces novel concepts and molecules that are currently being tested in preclinical and clinical models. Readers will find detailed information from leading experts on specific therapeutic strategies targeting the host immune and inflammatory system, the oral microbiome, and regeneration.
Sinem Esra Sahingur, DDS, MS, PhD, serves as the Associate Dean of Graduate Studies and Student Research at University of Pennsylvania, School of Dental Medicine. She is also Associate Professor in the Department of Periodontics and a Diplomate of American Board of Periodontology. Dr. Sahingur's continuously funded research program focuses on defining the role of immune and inflammatory pathways in periodontal disease pathogenesis, genetic and epigenetic susceptibility to periodontitis and the link between oral and systemic diseases. Sahingur and her team initiated the studies that revealed the involvement of nucleic acid sensing and ubiquitination in periodontal disease pathogenesis and more recently the link between oral cavity, gut, and liver axis and the effect of surfacing tobacco products, such as waterpipe smoking and e-cigarettes on human health. Dr. Sahingur has delivered numerous presentations at national and international meetings and published in leading journals. She was recognized for her outstanding achievements in research and teaching and received multiple awards including Undergraduate Research Opportunities Program (UROP) Outstanding Faculty Mentor Award and Dean's Award for Excellence in Research at VCU. In addition, Dr. Sahingur was also honored with the Women in Science, Dentistry and Medicine (WSDM) Award at VCU which is presented to distinguished female leaders in their respective fields.