Basal Cell Carcinoma. Advances in Treatment and Research

Chapter 1. Epidemiology and Risk Factors of Basal Cell Carcinoma - Waqas R. Shaikh and Zeena Y. Nawas
Chapter 2. Pathophysiology of Basal Cell Carcinoma and Its Associated Genetic Syndromes - Anne Lynn S. Chang
Chapter 3. Histopathology of Basal Cell Carcinoma and Its Variants - Priyadharsini Nagarajan, Michael T. Tetzlaff and Jonathan L. Curry
Chapter 4. Topical Therapy for the Treatment of Basal Cell Carcinoma - Natalie Kash and Sirunya Silapunt
Chapter 5. Local Immunotherapy for Basal Cell Carcinoma with Interferon - Hung Q. Doan and Stephen B. Tucker
Chapter 6. Cryotherapy and Electrodesiccation & Curettage for Basal Cell Carcinoma - Natalie Kash and Sirunya Silapunt
Chapter 7. Mohs Micrographic Surgery for the Treatment of Basal Cell Carcinoma - Leon Chen and Tri H. Nguyen
Chapter 8. Surgical Treatment for Basal Cell Carcinoma of the Head and Neck - Sagar Kansara, Christopher M.K.L. Yao and Neil D. Gross
Chapter 9. Special Considerations for Periocular Basal Cell Carcinoma - Oded Sagiv, Ho-Seok Sa and Bita Esmaeli
Chapter 10. Radiotherapy for Basal Cell Carcinoma - Sweet Ping Ng, Jae Phan, Danna K. Fullen, William H. Morrison and G. Brandon Gunn
Chapter 11. Photodynamic Therapy for the Treatment of Basal Cell Carcinoma - Natalie Kash and Sirunya Silapunt
Chapter 12. Laser Therapy for the Treatment of Basal Cell Carcinoma - Natalie Kash and Sirunya Silapunt
Chapter 13. Hedgehog Signaling Pathway Inhibitors for Basal Cell Carcinoma - Leon Chen, Sirunya Silapunt and Michael R. Migden
Chapter 14. Immunotherapy for Basal Cell Carcinoma - Leon Chen, Sirunya Silapunt and Michael R. Migden
Chapter 15. Treatment: Future Directions - Egle Ramelyte, Gaetana Restivo and Reinhard Dummer

Basal Cell Carcinoma: Advances in Treatment and Research provides a comprehensive overview of evidence-based treatment approaches for the most common cancer worldwide - basal cell carcinoma. The first part of this book details the epidemiology, risk factors, pathophysiology, and different histologic subtypes of basal cell carcinoma highlighted with high-resolution histopathology images. The second part of the book provides an in-depth review of different treatment modalities including topical therapy, local immunotherapy with interferon, cryotherapy, electrodesiccation and curettage, radiotherapy, and surgical approaches with Mohs micrographic surgery, head and neck surgery, and oculoplastic surgery. The final part of book highlights the utilization of innovative technology such as photodynamic therapy and laser for the treatment of basal cell carcinoma while providing excellent cosmetic outcome as well as emerging systemic therapeutic options utilizing hedgehog pathway inhibitors and immunotherapy for the difficult-to-treat disease state, advanced basal cell carcinoma.

Meant for a multi-disciplinary audience of dermatologists, Mohs Surgeons, oncologists, head and neck surgeons, oculoplastic surgeons, radiation oncologists, this book serves as an informative practical guide for physicians, mid-level providers and trainees. Basal Cell Carcinoma, is edited and written by leaders with expertise in cutaneous oncology, pathology, dermatology, Mohs micrographic surgery, plastic surgery, and many more specialties.

Michael R. Migden, MDAcademic Affiliation: Departments of Dermatology and Head and Neck SurgeryThe University of Texas MD Anderson Cancer CenterHouston, TX, USA

Dr. Migden, professor, departments of dermatology and head and neck surgery at MD Anderson Cancer Center, specializes in Mohs micrographic surgery, complex reconstruction, and clinical research in cutaneous oncology. He is the principal investigator of various clinical trials that evaluate the use of hedgehog pathway inhibitors and immunotherapy for advanced nonmelanoma skin cancer, devices for detection of cutaneous malignancy and methods for documenting skin biopsy site location for treatment. His research has been published in the New England Journal of Medicine, Lancet Oncology, and other high impact peer-reviewed journals. Dr. Migden is the author of multiple book chapters and speaks nationally and internationally on cutaneous reconstruction, hedgehog pathway inhibitors, immunotherapy therapy, and the use of digital media in surgical education.

Leon Chen, MDAcademic Affiliation: Department of DermatologyThe University of Texas McGovern Medical School at Houston,Houston, Texas, USADepartment of Dermatology The University of Texas MD Anderson Cancer CenterHouston, TX, USA

Dr. Chen received his medical degree from the University of Texas McGovern Medical School at Houston and continued his fellowship training for Micrographic Surgery and Dermatologic Oncology (Mohs) at MD Anderson Cancer Center after completing dermatology residency at the MD Anderson Cancer Center/University of Texas McGovern Medical School combined program. Dr. Chen's deep passion for cutaneous oncology has led him to author numerous research manuscripts, and his research has been presented at national and international dermatology meetings. His clinical interests include treating skin cancers with both surgical and non-surgical modalities.

Sirunya Silapunt, MDAcademic Affiliation: Department of DermatologyThe University of Texas McGovern Medical School at Houston,Houston, Texas, USA

Dr. Silapunt is a board-certified dermatologist and currently serves as an associate professor of the Department of Dermatology at The University of Texas McGovern Medical School at Houston. She is a faculty in Micrographic Surgery & Dermatologic Oncology Fellowship Program, clinical associate professor at MD Anderson Cancer Center, and an associate program director for the American Society of Dermatologic Surgery (ASDS) Cosmetic Dermatologic Surgery Fellowship Accreditation Program. Dr. Silapunt treats a wide variety of skin conditions and a large part of her practice consists of skin cancer and varicose vein treatments. Dr. Silapunt also has a special focus in laser and cosmetic dermatology. Dr. Silapunt has authored more than 50 peer-reviewed research manuscripts and numerous book chapters. She is an editor of the textbook "Treatment of Leg Veins, 2nd