Diminished Ovarian Reserve and Assisted Reproductive Technologies. Current Research and Clinical Management

Part I: The paradigm of diminished ovarian reserve, conventional & adjuvant treatment approaches for assisted reproductive technologies. 1. Introduction: The Scope of the Problem of Diminished Ovarian Reserve.- 2. Ovarian and Hypothalamic Aging.- 3. Natural History of Diminished Ovarian Reserve.- 4. Definitions and Relevance: Diminished Ovarian Reserve, Poor Ovarian Response, Advanced Reproductive Age, Premature Ovarian Insufficiency.- 5. Food Supplements and Hormonal Products to Improve Assisted Reproductive Technology Outcomes in Diminished Ovarian Reserve Patients.- 6. Traditional Chinese Medicine for Assisted Reproductive Technology.- 7. Controlled Ovarian Stimulation Protocols for IVF: From First IVF baby in the United States and Beyond.- 8. Conventional Controlled Ovarian Stimulation Protocols for Diminished Ovarian Reserve Patients and Poor Responders.- 9. Natural Cycle Approaches for ART.- Part II: Minimal and Mild Stimulation Protocols.- 10. The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) Definitions for Mild Stimulation and Their Rationale for Assisted Reproductive Technologies.- 11. Current Outlook of Minimal and Mild Stimulation Protocols for Assisted Reproductive Technologies in Women with Diminished Ovarian Reserve and/or Advanced Reproductive Age.- 12. Minimal Stimulation Protocol for Assisted Reproductive Technologies in Women with Diminished Ovarian Reserve and/or Advanced Reproductive Age.- 13. Mild Stimulation Alternatives to Minimal Stimulation.- 14. Control of Luteinizing Hormone (LH).- 15. Preventing Premature Ovulation.- 16. Trigger Agents and Post-trigger Testing.- 17. Oocyte retrieval.- 18. Fertilization: Conventional IVF versus ICSI.- 19. Embryo Culture: Cleavage versus Blastocyst Stage.- 20. Endometrial Considerations for Minimal Stimulation.- 21. Frozen Embryo Transfer Preparation.- 22. Minimal and Mild Stimulation IVF Results.- Part III: Utilization of Contemporary Technologies in Diminished Ovarian Reserve Patients.- 23. Fresh versus Frozen Embryo Transfer.- 24. Comprehensive Chromosome Analysis in Diminished Ovarian Reserve Patients.- Part IV: Future Prospects.- 25. Artificial Oocyte and Artificial Ovary Development.- 26. Activation of Ovarian Cortex.- 27. Oocyte Freezing at an Earlier Age.- 28. Ovarian Cortical Tissue Biopsy for Freezing and Auto Transplantation.

This book brings together the most current research and the latest clinical approaches to the management of diminished ovarian reserve (DOR), one of the largest segments of the IVF patient population, both in the advanced reproductive age group as well as poor responders. Opening with a review of the definition and scope of the problem, as well as the current understanding of the natural history of DOR, subsequent chapters in part I outline dietary, hormonal, traditional supplements and conventional methods used to stimulate ovaries and improve ART outcomes. The main segment of chapters, comprising part II, present minimal and mild stimulation protocols and alternatives, frozen embryo transfer preparation, trigger agents and post-trigger testing, embryo culture and endometrial considerations, and a review of clinical outcomes. Part III discusses the utilization of contemporary technologies in the treatment of DOR, including fresh vs. frozen embryo transfer, cryopreservation and comprehensive chromosomal analysis. Future prospects are presented in part IV, such as the artificial oocyte and ovary development, early-age oocyte freezing, ovarian cortical tissue freezing and activation of the ovarian cortex.

Utilizing the latest evidence and authored by an international array of thought leaders, Diminished Ovarian Reserve and Assisted Reproductive Technologies is an excellent resource for reproductive medicine and REI specialists, IVF lab professionals, and students and residents in these areas.

Orhan Bukulmez, MD, Associate Professor and Division Director, Division of Reproductive Endocrinology and Infertility; Practice and Medical Director, Fertility and Advanced Reproductive Medicine Assisted Reproductive Technology Program; Medical Director, UT Southwestern Fertility Clinic; Chief, Gynecologic Endocrinology Service, Parkland Health and Hospital System; Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA