Part 1: Anatomy and Physiology.- Chapter 1: Anatomy and Pharmacology of Vessels.- Chapter 2: Physiology of Vessels.- Chapter 3: Cell Biology of Vessels.- Chapter 4: Stem Cell Biology and the Cardiovascular System.- Chapter 5: The Lymphatic System.- Chapter 6: Imaging the vascular wall; from microscope to virtual reality.- Chapter 7: Clinical Cardiovascular Imaging.- Part 2: Pharmacology and Signalling.- Chapter 8: Vascular Signalling.- Chapter 9: Vasoactive Peptides: Renin Angiotensin System.- Chapter 10: Aldosterone.- Chapter 11: Nitric Oxide.- Chapter 12: Reactive Oxygen Species.- Chapter 13: TGF-beta in Vascular Pathobiology.- Chapter 14: miRNA and IncRNA in the Vascular System.- Chapter 15: Microparticles and Exosomes in Cell-Cell Communication.- Part 3: Pathophysiology of Vascular Diseases.- Chapter 16: Genomics of Hypertension.- Chapter 17: Endothelial Dysfunction.- Chapter 18: Vascular Remodelling.- Chapter 19: Vascular Stiffness.- Chapter 20: Atherosclerosis.- Chapter 21: Inflammation and Immunity in Vascular Diseases.- Chapter 22: Diagnostic and therapeutic targeting of inflammation.- Chapter 23: Perivascular Adipose Tissue.- Chapter 24: Vascular Biology of Chemotherapeutic Drugs.- Chapter 25: Coronary Microvascular Disease.- Chapter 26: Cerebral Small Vessel Disease and Vascular Cognitive Impairment: Preclinical Aspects.- Chapter 27: Ethnicity and Cardiovascular Disease.- Part 4: Clinical Aspects.- Chapter 28: Epidemiology of Vascular Diseases.- Chapter 29: Early Vascular Ageing and Healthy Vascular Ageing.- Chapter 30: Biomarkers of Cardiovascular Disease.- Chapter 31: Hypertension.- Chapter 32 Diabetic Retinopathy.- Chapter 33: Ischaemic Heart Disease.- Chapter 34: Pre-eclampsia.- Chapter 35: Stable Coronary Artery Syndromes.- Chapter 36: Heart Failure: HFrEF.- Chapter 37 Heart Failure: HFpEF.- Chapter 38 Renal Disease.- Chapter 39 Obesity.- Chapter 40 Diabetes.- Chapter 41 Pulmonary.- Hypertension.- Chapter 42 Cerebral Small Vessel disease and Vascular Cognitive Impairment.- Chapter 43 Stroke.- Chapter 44 Peripheral Vascular Disease.- Chapter 45 Vascular malformations and tumours.
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons.
This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease).
The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Professor Rhian M. Touyz, MBBCh, MSc(Med), PhD, FRCP, FRSE, FAHA, FCAHS, FESC, FMedSci. is Director of the Institute of Cardiovascular & Medical Sciences (ICAMS) and British Heart Foundation (BHF) Chair of Cardiovascular Medicine, University of Glasgow. She also directs the BHF Centre of Research Excellence in Vascular Science and Medicine, ICAMS. She is a clinician-scientist focusing on vascular biology of hypertension, and is honorary consultant in the Blood Pressure Unit at the Queen Elizabeth University Hospital. She was the Canada Research Chair in Hypertension at the Kidney Research Centre, Ottawa Hospital Research Institute, Univ of Ottawa, Canada until 2011 when she moved to Glasgow. Dr Touyz received her BSc(Hons)(1980), MBBCh(1984), MSc(1986) and PhD(1992) from the University of Witwatersrand, South Africa. She completed a post-doctoral fellowship at the Clinical Research Institute in Montreal. She has received numerous awards, including the Dahl Award and the Harriet Dustan Research Award (American Heart Association (AHA)), Robert M. Berne Distinguished Award (American Physiological Society), RD Wright Award (BP Research Council, Australia), Irvine Page Award (American Society of Hypertension) and the Joan Mott Award (Physiology Society). Prof Touyz co-chaired the Canadian Hypertension Education Program for clinical guidelines and is a member of the Committee for Practice Guidelines of the European Society of Cardiology. She was President of the Canadian Hypertension Society, Chair of the High Blood Pressure Research Council (AHA), and President of the International Society of Hypertension. She is the President of the European Council for Cardiovascular Research. She is Editor-in-Chief of Clinical Science, Deputy Editor of Hypertension, and Associate Editor of Pharmacological Reviews.
She has trained over 60 PhD students and fellows, many of whom have gone on to successful independent careers. Her research focuses on vascular biology of cardiovascular disease and in particular: 1) molecular mechanisms, redox signaling and vascular biology of hypertension; 2) cardiovascular toxicity of anti-cancer drugs (VEGF inhibitors), 3) small vessel disease and complications of hypertension, and 4) vascular biology of cations and TRPM ion channels. She has a particular interest in translational and clinical research.
Professor Christian Delles, MD, FRACP, FAHA, FBHS, is Professor at the Institute for Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. He is the Deputy-Director of the British Heart Foundation Centre of Research Excellence in Vascular Science and Medicine, ICAMS, University of Glasgow and he is a Consultant Physician at the Queen Elizabeth University Hospital. After graduating from the University of Freiburg, Germany, and working for his MD Thesis at the University of Innsbruck, Austria, he trained in internal medicine and nephrology at the Department of Nephrology, University of Erlangen-Nurnberg, Germany. In 2003 he was awarded a fellowship by the Deutsche Forschungsgemeinschaft for studies into reactive oxygen species in hypertension in Prof. Anna Dominiczak's group in Glasgow. He has been a lead investigator in numerous large network research projects funded by the European Commission.
He is interested in the initiation and progression of cardiovascular diseases and studies subclinical organ damage. Prof. Delles has published more than 200 peer reviewed papers. He is a member of national and international hypertension societies including the Deutsche Hochdruckliga, British Irish Hypertension Society, European Society of Hypertension, International Society of Hypertension and the Council on Hypertension of the American Heart Association. He has assumed leadership roles in the British Irish Hypertension Society and European Society of Hypertension. He is Associate Editor of Clinical Science and Cardiovascular Research and on the editorial board of major cardiovascular journals including Hypertension and Journal of Hypertension. Prof. Delles teaches on hypertension and cardiovascular diseases and their pathogenesis at undergraduate and postgraduate level, supervises MD and PhD students and is engaged in clinical academic training in Glasgow.