Coronary Stenosis. Imaging, Structure and Physiology

“Coronary stenosis. Imaging, structure and physiology” has been designed as a clinically and research orientated reference for all cardiologists, physicians, cardiovascular imagers, trainees and investigators working in the field of ischemic heart disease. In the scenario of facilitated access to the coronary arteries provided by new diagnostic techniques, this book comes to fill an empty space in the medical literature: a textbook providing a comprehensive, multifaceted analysis of atherosclerotic and non atherosclerotic coronary stenoses, addressing multiple issues that are of key importance in invasive and non-invasive
diagnostic studies of the coronary vessels.

Emphasis has been placed in integrating three separate aspects: imaging, structure and physiology. The chapters are written by top experts in invasive and noninvasive diagnostics, coronary anatomy, pathology and physiology, encouraged by the editors to adress each topic from a plural perspective to facilitate knowledge sharing between their respective disciplines. An associated website provides access to the electronic edition of the book, which includes moving images and updated material.

“An indispensable companion for all those involved in the diagnosis and treatment of ischemic heart disease.”

EDITOR’S BIOGRAPHY

Javier Escaned MD PhD FESC studied at the University of Santiago de Compostela (Spain), and trained at the United Kingdom (Queen Elizabeth Hospital at Birmingham and Walsgrave Hospital at Coventry) and The Netherlands (Thoraxcenter / Erasmus MC). In 1994 he read his PhD thesis in Erasmus University Rotterdam (The Netherlands). In 1997 he was appointed Consultant Interventional Cardiologist at Hospital Clínico San Carlos, Madrid, Spain, a leading European institution in the field where he continues his clinical and research endeavours. He is author of more than 150 scientific articles and books chapters, mostly on interventional cardiology, intracoronary diagnostic techniques, coronary physiology and pathobiology of coronary atheroma.

Patrick W. Serruys MD PhD FESC FACC is Professor of Interventional Cardiology and Head of Interventional Department at Erasmus MC University Medical Center, Rotterdam (The Netherlands) and directs the Interventional Department there. His primary research interests are coronary artery disease and interventional cardiology, for which he has received numerous awards. He is also a Fellow of the European Society of Cardiology and the American College of Cardiology, and a member of the Scientific Council of the International College of Angiology. He is Associate Editor of Circulation and serves on the editorial boards of several other journals. Dr Serruys has published more than 1300 papers and co–edited 31 books.

BOOK’S CONTENT

Foreword - Morton J. Kern

Preface - Javier Escaned, Patrick W. Serruys

Part I - The hemodynamics of coronary stenoses

• Anatomy and structure of the coronary circulation
  Robert H. Anderson, Tony Hlavacek
• Fundamental concepts of coronary physiology for clinicians
  Jos Spaan, Jan Piek
• Hemodynamic effects of focal and diffuse coronary stenoses
  Rob Krams
• Interactions between coronary stenoses and microcirculation
  Mario Marzilli
• Physiology of collateral circulation
  Gerald Werner

Part II - The structure of coronary stenoses

• Evolution of atheromatous plaques
  Renu Virmani
• Vessel remodelling during atherogenesis
  Pilar Jimenez, Javier Escaned
• Assessment of metaloproteinase plaque elution in unstable plaques
  Hiroshi Suzuki
• Intracoronary thrombosis and stenosis
  Dominick Angiolillo
• Structure of chronic total occlusions
  Bradley Strauss
• Vasa vasorum in healthy and diseased coronary vessels
  Amir Lerman

Part III - Assessment of coronary atheroma

• A historical perspective of the angiographic assessment of coronary stenoses
  John Ambrose
• Contemporary angiographic assessment of coronary stenoses
  Chris Girasis, Patrick W. Serruys
• Assessment of coronary stenoses using gray-scale intravascular ultrasound
  Carlo Di Mario
• Ultrasonic characterisation of atheromatous plaque components
  Hector García
• Angioscopic assessment of coronary stenoses
  Fernando Alfonso
• Near infrarred spectroscopy
  James Muller
• Optical coherence tomography in the assessment of coronary stenoses
  Nieves Gonzalo, Evelyn Regar
• Intracoronary thermography in the assessment of plaque inflammation
  Konstantinos Totouzas
• Elastographic assessment of coronary stenoses
  AFW van der Steen
• Non-invasive study of coronary stenoses with MSCT
  Koen Nieman, Pim de Feyter
• Assessment of atheromatous plaques with magnetic resonance imaging
  Juan Luis Jimenez-Borreguero, Valentin Fuster
• Plaque assessment with Raman spectroscopy
  James F. Brennan 3rd

Part IV - Functional assessment of coronary stenoses

• Radionuclide assessment of myocardial ischemia
  Philipp A. Kaufmann
• Ecocardiographic assessment of myocardial ischemia
  José Luis Zamorano, Alejandro Cortell
• Assessment of myocardial ischemia with nuclear magnetic resonance
  Ingo Paetsch, Jesús González-Mirelis
• Intracoronary pressure and thermodilution measurements
  Volker Klauss
• Intracoronary Doppler-based techniques for stenosis assessment
  Maria Siebes

Part V - Dynamic coronary stenoses

• Physiology and clinical assessment of myocardial bridges
  Javier Escaned
• Coronary spasm: pathophysiology and diagnosis
  Filippo Crea
• Spontaneous coronary dissection
  Vera Lennie, Manuel Paulo Guzman
• Congenital coronary anomalies causing extravascular vessel compression
  Tony Hlavacek, Robert H. Anderson

Part VI - Coronary stenoses after cardiac interventions

• Saphenous vein graft attrition
  Gianni Angelini, Jean-Louis Sablayrolles
• Restenosis in bare metal and drug eluting stents
  Adnan Kastrati
• Coronary stenoses in transplant graft vasculopathy
  Javier Segovia