· The first book to focus on the state of art of overall focal therapy
· The first book to address this topic in depth
· Presents contributions by the world’s best teams involved in this new therapy development
Focal therapy is a compelling option for selected patients who have unilateral low-risk prostate cancer, providing an alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Early feasibility studies have investigated cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have promising oncological outcomes. These various ablative techniques have resulted in limited rectal toxicity, had minor effects on urinary function and demonstrated a high rate of preserving erectile function. As a result, the primary end-point has now shifted and a new strategy needs to be set up for patient follow-up and for defining treatment failure.
Table of contents
Rational for Focal Therapy.- Concept of Index lesion.- Definition and Principles of Focal Therapy.- Eligibility for Focal Therapy: Patient Selection.- Imagingfor Focal Therapy.- Biopsies strategy.- Focal Cryotherapy.- Focal HIFU.- Focal Brachytherapy.- Focal PhotoDynamic Therapy.- Focal Laser Thermal Therapy.- Cyberknife Focal Therapy.- New Energies.- Follow-up after Focal Therapy.- Failure or Recurrence Management.- Focal Therapy Limitations.- Perspective.- Conclusion.