Diabetic Retinopathy

About this book

Diabetic retinopathy is the most common microvascular complication of diabetes. It remains a major cause of new-onset visual loss in the United States and other industrialized nations. In Diabetic Retinopathy, Elia Duh and a panel of internationally recognized experts comprehensively assess the current state of knowledge regarding the clinical management of DR as well as its underlying mechanisms. The authors outline the current understanding of diabetic retinopathy from the perspective of clinical practice, while reviewing the multi-factorial pathogenesis and pathophysiology of DR from the standpoint of biomedical research. Also included is a discussion of emerging concepts relating to the management and treatment of DR. Informative and highly-practical, Diabetic Retinopathy provides ophthalmologists, diabetologists, endocrinologists, and internists with a highly readable guide not only to understanding diabetic retinopathy, but also to its optimal clinical management.

Written for: Ophthalmologists, diabetologists, endocrinologists, and internists

Keywords:

• Diabetes
• Microvascular
• Oxidative Stress
• Retinal Neovascularization
• Retinopathy
• Therapeutic Strategies
• Vascular Permeability

Table of contents

Part I: Clinical Aspects of Diabetic Retinopathy

• Nonproliferative Diabetic Retinopathy (Catherine B. Meyerle, Emily Y. Chew, and Frederick L. Ferris III)
• Proliferative Diabetic Retinopathy (Ronald P. Danis and Matthew D. Davis)
• Epidemiology of Diabetic Retinopathy (Ronald Klein)
• Diagnostic modalities in Diabetic Retinopathy (Ron Margolis and Peter K. Kaiser)

Part II: Pathophysiology/Basic Research

• In vivo models of diabetic retinopathy (Timothy S. Kern)
• Pathways of hyperglycemia-induced Damage
• The Polyol Pathway and Diabetic Retinopathy (Mara Lorenzi and Peter J. Oates)
• The Role of Advanced Glycation in Diabetic Retinopathy (Alan W. Stitt)
• The Role of Protein Kinase C in Diabetic Retinopathy (Manvi Prakash, Jennifer K. Sun, and George L. King)
• Oxidative Stress in Diabetic Retinopathy (Ruth B. Caldwell, Azza E.B. El-Remessy, and Robert W. Caldwell)
• Pathophysiological Processes in Diabetic Retinopathy
• Pericyte Loss in the Diabetic Retina (Frederick Pfister, Yuxi Feng, and Hans-Peter Hammes)
• Capillary Dropout in Diabetic Retinopathy (Renu A. Kowluru, Pooi-See Chan, Bindu Menon)
• Neuroglial Dysfunction in Diabetic Retinopathy (Heather D. VanGuilder, Thomas W. Gardner, and Alistair J. Barber)
• The Role of Inflammation in the Pathophysiology of Diabetic Retinopathy (Lauren E. Swenarchuk, Linda E. Whetter, and Anthony P. Adamis,)
• Vascular Permeability in Diabetic Retinopathy (David A. Antonetti, Heather D. VanGuilder, Cheng Mao-Lin)
• Retinal neovascularization and the role of VEGF (Elia J. Duh)
• Beyond VEGF – Other Factors Important in Retinal Neovascularization: Potential Targets in Proliferative Diabetic Retinopathy(Arup Das, Deepti Navaratna, and Paul G. McGuire)

Part III: Emerging Treatments and Concepts in Diabetic Retinopathy

Anti-VEGF therapy as an emerging treatment for diabetic retinopathy (Diana V. Do, Julia A. Haller, Anthony P. Adamis, Carla Striata, Quan Dong Nguyen, Syed Mahmood Shah, and Antonia M. Joussen)

Clinical Trials in Protein Kinase C-ß Inhibition in Diabetic Retinopathy (Jennifer K. Sun, Rola Hamam, Lloyd P. Aiello)

The role of intravitreal steroids in the management of diabetic retinopathy (Mark C Gillies)

Antagonism of the Growth Hormone Axis as a Therapeutic Strategy for Diabetic Retinopathy (Alexander V. Ljubimov, Michael Boulton, Sergio Caballero, and Maria B. Grant)

Diabetic Retinopathy and Systemic Complications (Ning Cheung and Tien Y Wong)