Allogeneic Stem Cell Transplantation

About this book

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Written for: Clinicians and researchers in allogeneic HSC transplantation

Keywords:

allogeneic graft technology
allogeneic stem cell
allografts
hematopoietic stem cell
immune reconstitution
stem cell transplantation

Table of contents

Chapter 1 - Allogeneic Stem Cell Transplantation – The Last Century
John M Goldman DM FRCP FMedSci

Chapter 2 – Full Intensity and Reduced Intensity Allogeneic Transplantation in AML
Charles Craddock, MD

Chapter 3 – Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia
Bella Patel, MD, Anthony H Goldstone, MD and Adele K. Fielding, MD

Chapter 4 – Hematopoietic Progenitor Cell Transplantation for Treatment of Chronic Lymphocyctic Leukemia
Leslie A. Andritsos, MD, John C. Byrd, MD and Steven M. Devine, MD

Chapter 5 – The Role of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia Patients in the Era of Tyrosine Kinase Inhibitors
Richard T. Maziarz, MD

Chapter 6 – Allogeneic Transplantation for Hodgkin’s Lymphoma
William Broderick, MD and Patrick Stiff, MD

Chapter 7 – Myeloblative Allogeneic Stem Cell Transplantation for Non-Hodgkin’s Lymphoma
J. Kuruvilla, MD, P. Mollee, MD and JH Lipton, MD, PhD.

Chapter 8 – Non-Hodgkin’s Lymphoma: Allogeneic Reduced Intensity Conditioning
Sonali M. Smith, M.D. and Ginna G. Laport, MD

Chapter 9 – The Role of Allogeneic Transplantation for Multiple Myeloma in Older Adults
Heidi D. Klepin, MD and David D. Hurd, MD

Chapter 10 – Single versus Tandem Autologous Hematopoietic Stem Cell Transplant in Multiple Myeloma
David H. Vesole, MD, PhD, FACP

Chapter 11 – Treatment Strategies for Follicular Center Cell Non-Hodgkin’s Lymphoma
Frank Heinzelmann, MD, Hellmut Ottinger, MD and Claus Belka, MD

Chapter 12 – The Role of Transplantation in Favorable – Risk Acute Myeloid Leukemia
Mickey Liao, MD and Gary J. Schiller, MD

Chapter 13 – Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adults
David I. Marks, MD

Chapter 14 – Allogeneic Transplantation for Myelodysplastic Syndromes
Geoffrey L. Uy, MD and John F. DiPersio, MD, PhD.

Chapter 15 – Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia
Adriana Balduzzi, MD, Lucia Di Maio, MD, Mary Eapen, MD and Vanderson Rocha, MD, PhD.

Chapter 16 – Allogeneic Transplantation for the Treatment of Multiple Myeloma
Rebecca L. Olin, MD, Dan T. Vogl, MD and Edward A. Stadtmauer, MD

Chapter 17 – Blood vs Marrow Allogeneic Stem Cell Transplantation
Brian McClune, DO and Daniel Weisdorf, MD

Chapter 18 – Hematopoietic Cell Transplantation from Partially HLA- Mismatched (HLA-Haploidentical) Related Donors
Ephraim J. Fuchs, MD and Heather J. Symons, MD

Chapter 19 – Unrelated Donor Transplant
Andrea Bacigalupo, MD

Chapter 20 – Update on Umbilical Cord Blood Transplantation
Karen Ballen, MD

Chapter 21 – Selection of Cord Blood Unit(s) for Transplantation
Donna A. Wall, MD and Ka Wah Chan, MD

Chapter 22 – Mobilization of Hematopoietic Cells Prior to Autologous or Allogeneic Transplantation
Steven M. Devine, MD

Chapter 23 – Natural Killer-Cell Based Treatment in Hematopoetic Stem Cell Transplantation
Martin Stern, MD, Sandrine Meyer-Monard, MD, Uwe Siegler, MD, Jakob R Passweg, MD

Chapter 24 – Cryopreservation of Allogeneic Stem Cell Products
Noelle V. Frey, MD and Steven C. Goldstein, MD

Chapter 25 – Concepts and Controversies in the Use of Novel Preparative Regimens for Allogeneic Stem Cell Transplantation
Steven C. Goldstein, MD and Selina Luger, MD

Chapter 26 – Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) and Natural Killer (NK) Cell Alloreactivity
Franco Aversa, MD and Andrea Velardi, MD

Chapter 27 – Therapeutic Potential of Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation
Luis A. Solchaga, PhD and Hillard M. Lazarus, MD, FACP

Chapter 28 – Hematopoietic Stem Cell Transplantation for Thalassemia
Javid Gaziev, MD and Guido Lucarelli, MD

Chapter 29 – Viral Infections in Hematopoietic Stem Cell Transplant Recipients
Per Ljungman, MD

Chapter 30 – Fungal Infections
John R. Wingard, MD

Chapter 31 – Immune Reconstitution Following Allogeneic Stem Cell Transplantation
Kristen M. Williams, MD and Ronald E. Gress, MD

Chapter 32 – Acute Graft Versus Host Disease: Prophylaxis
Corey Cutler, MD, MPH, FRCP (C), Vincent T. Ho, MD and Joseph H. Antin, MD

Chapter 33 – Chronic Graft versus Host Disease
Madan Jagasia, MBBS, MS and Steven Pavletic, MD

Chapter 34 – Post-Transplant Lymphoprolifeative Disorder
Ran Reshef, MD, Alicia K. Morgans, MD and Sonald E. Tsai, MD, PhD

Chapter 35 – Psychological Care of Adult Allogeneic Transplant Patients
Flora Hoodin, PhD., Felicity W. K. Harper, PhD. and Donna M. Posluszny, PhD.

Chapter 36 – Second Allegeneic Transplantation: Outcomes and Indications
Koen van Besien, MD, Dan Pollyea, MD and Andrew Artz, MD

Chapter 37 – Minimal Residual Disease
Mehmet Uzunel, PhD.

Chapter 38 – Functional Assessment Tools and Co-Morbidity Scoring in Hematopoietic Progenitor Cell Transplantation
Sergio Giralt, MD and Uday Popat, MD

Chapter 39 – Unique Thrombotic and Hemostatic Complications Associated with Allogeneic Hematopoietic Stem Cell Transplantation
Amber A. Petrolla, MD, Hillard M. Lazarus, MD, FACP and Alvin Schmaier, MD

Chapter 40 – How Much Isolation is enough for Allografts?
Brandon Hayes-Lattin, MD

Chapter 41 – Monoclonal Antibodies in Allogeneic Hematopoietic Stem Cell Transplantation for Hematologic Malignancies
Maria Corinna Palanca-Wessels, MD, PhD. and Oliver Press, MD, PhD.

Chapter 42 – Treatment of Acute Graft Vs Host Disease
Steven C. Goldstein, MD, Sophie D. Stein, MD and David L. Porter, MD

Chapter 43 – The Importance of Non – Human Primate Models for Pre-Clinical Studies in Hematopoiesis
Erzebet Szilagyi, MD, PhD, Nadim Mahmud, MD, PhD and Amelia Bartholomew, MD

Chapter 44 – In vivo Models of Allogeneic Hematopoietic Stem Cell Transplantation
Lisbeth A. Welniak, MD and William J. Murphy, MD

Chapter 45 – Dendritic Cells (DCs)
Jacalyn Rosenblatt, MD and David Avigan, MD

Chapter 46 – Augmentation of Hematopoietic Stem Cell Transplantation with Anti-Cancer Vaccines
Edward D. Ball, MD and Peter R. Holman, MD